Sains Malaysiana 36(1): 21-26 (2007)

Synthesis and Characterization of Some Diorganotin(IV) Complexes

of 2,3-Dihydroxybenzaldehyde N(4)-Substituted Thiosemicarbazone

(Sintesis dan Pencirian Kompleks Diorganostanum(IV) dengan

N(4)- Tiosemikarbazon Terbitan 2,3-Dihidroksibenzaldehid)

Abdurazag T. Swesi, Yang Farina & Ibrahim Baba

School of Chemical Sciences and Food Technology

Faculty of Science and Technology, Universiti Kebangsaan Malaysia

43600 UKM Bangi, Selangor, Malaysia 

ABSTRAK

Sebatian organostanum terutama terbitan dialkilstanum dilaporkan mempunyai sifat anti-tumor. Kompleks diorganostanum(IV) jenis Me₂SnL¹, Me₂SnL², Bu₂SnL¹, Bu₂SnL² dan Ph₂SnL¹ (L¹H₂ dan L²H₂ adalah anion ligan tiosemikarbazon yang terbentuk daripada tindak balas kondensasi 2,3-dihidroksibenzaldehid dengan tiosemikarbazida atau penukarganti N(4)-metilnya) telah disintesis menggunakan nisbah logam kepada ligan, 1:1. Kompleks yang terhasil dicirikan secara analisis unsur dan teknik spektroskopi inframerah dan resonans magnet nukleus (¹H, ¹³C, ¹¹⁹Sn). Pembentukan kompleks di antara moieti organostanum(IV) dengan anion 2,3-dihidroksibenzaldehid tiosemikarbazon dan 2,3-dihidroksibenzaldehid 4-metiltiosemikarbazon berlaku dengan pengelatan pada kedudukan o-dihidroksi. Kompleks dicadangkan mempunyai geometri tetrahedron.

Kata kunci: sintesis; organostanum; tiosemikarbazon 

ABSTRACT 

Organotin compounds especially the dialkyltin derivatives are reported to possess anti-tumour properties. The diorganotin(IV) complexes of the type Me₂SnL¹, Me₂SnL², Bu₂SnL¹, Bu₂SnL² and Ph₂SnL¹ (L¹ and L² is the anion of the thiosemicarbazone ligand formed by the condensation reaction of 2,3-dihydroxybenzaldehyde with thiosemicarbazide or its N(4)-methyl substituent) were synthesized using 1:1 metal-to-ligand reactant ratios. The newly synthesized complexes were characterized using elemental analysis, infrared and nuclear magnetic resonance (¹H, ¹³C, ¹¹⁹Sn) spectroscopic techniques. Complex formation between the organotin(IV) moiety and the anions of 2,3-dihydroxybenzaldehyde thiosemicarbazone and  2,3-dihydroxybenzaldehyde 4-methylthiosemicarbazone occurred with chelation at the o-dihydroxy positions. The complexes are proposed to have tetrahedral geometry.

Keywords: synthesis; organotin; thiosemicarbazones

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