Sains Malaysiana 41(5)(2012): 591–595

Curcumin as an Anti-Arthritic Agent in Collagen-InducedArthritic Sprague-Dawley Rats

(Kurkumin sebagai Suatu Agen Antiartritik untukTikus Sprague-Dawley yang Mengalami Artritis Aruhan Kolagen)

A.F. Zahidah

Department of Biomedicine Science, Faculty of Allied Health Sciences , Universiti Kebangsaan Malaysia

Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

O. Faizah, K. Nur Aqilah & K. Taty Anna*

Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia

Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

Received: 16 May 2011/Accepted: 2 November 2011

ABSTRACT

Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumatoid arthritis (RA) due to inflammatory reactions. In this study, collagen-induced arthritis (CIA) model was utilized to study the effects of curcumin on joint inflammation in Sprague-Dawley rats. Body weight measurement, arthritis score assessment and radiology score assessment were carried out at specific intervals throughout this study. The results showed that the mean arthritis and radiology scores for animal groups designated as CIA Curcumin^Cand CIA Curcumin^Twere significantly lower compared with the negative control (CIA OV) group respectively. The mean arthritis scores for CIA Curcumin^Cgroup is significantly lower compared with CIA Curcumin^Tgroup but there is no significant difference in the mean radiology scores between the CIA Curcumin^Cand CIA Curcumin^Tgroups. In conclusion, the oral supplementation of curcumin at the dose of 110 mg/mL/kg/day has a potential to delay and improve joint abnormality and injury in Sprague-Dawley rats with CIA.

Keywords: Arthritis score; collagen-induced arthritis; curcumin; radiology score

ABSTRAK

Curkuma longa atau kunyit telah lama digunakan dalam perubatan tradisi oleh penduduk tempatan di Malaysia sebagai agen antiinflamasi. Ia terbukti mengandungi agen antiartritik semula jadi iaitu Kurkumin. Ketaknormalan pada sendi terlibat dalam patogenesis artritis reumatoid (RA) disebabkan tindak balas inflamasi. Dalam kajian ini, model artritis aruhan kolagen (CIA) telah digunakan untuk mengkaji kesan Kurkumin ke atas sendi tikus Sprague-Dawley. Sepanjang penyelidikan ini, pengukuran berat badan, penilaian skor artritis dan penilaian skor radiologi dilakukan pada selang masa tertentu. Hasil kajian menunjukkan bahawa purata skor artritis dan purata skor radiologi bagi kumpulan CIA Kurkumin^Cdan CIA Kurkumin^Tmasing-masing adalah lebih rendah secara signifikan berbanding kumpulan kawalan negatif (CIA OV). Purata skor artritis bagi kumpulan CIA Kurkumin^Cadalah rendah secara signifikan berbanding kumpulan CIA Kurkumin^Ttetapi tiada perbezaan yang tekal pada purata skor radiologi antara kumpulan CIA Kurkumin^Cberbanding kumpulan CIA Kurkumin^T. Kesimpulannya, suplemen oral kurkumin sebanyak 110 mg/mL/kg/hari berpotensi memperlahan dan memperbaiki ketaknormalan serta kecederaan pada sendi tikus Sprague-Dawley yang mengalami CIA

Kata kunci: Artritis aruhan kolagen; kurkumin; skor artritis; skor radiologi

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* Corresponding author; email: tatykamarudin@gmail.com