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Sains Malaysiana 46(10)(2017):
1859–1863 http://dx.doi.org/10.17576/jsm-2017-4610-24
Anti-nociceptive Effect of Caralluma
edulis on Peripheral and Central Pain Pathways (Kesan Anti-nosiseptik
Caralluma edulis terhadap
Sistem Sakit
Berpusat dan Periferal) SUNDAS FIRDOOS1,
ARIF-ULLAH KHAN1* & FAWAD ALI1,2 1Department
of Basic Medical Sciences, Riphah Institute
of Pharmaceutical Sciences, Riphah
International University, Islamabad, Pakistan 2Department of Pharmacy, Kohat University of Science and Technology, Kohat,
Pakistan Received:
7 May 2016/Accepted: 29 March 2017 ABSTRACT The purpose of the present
research was to evaluate the phytochemical content and analgesic
effect of Caralluma edulis (Ce.Cr). Established methods
were used for phytochemical analysis of plant. The anti-nociceptic
activity of Ce.Cr was scrutinized
using acetic acid-induced writhings,
tail immersion and hot plate methods. Ce.Cr
was tested positive for the presence of therapeutically active
metabolites such as alkaloids, flavonoids, glycosides, phenol,
tannins, terpenoids and saponins. Ce.Cr at the dose of 10,
30 and 100 mg/kg inhibited acetic acid-induced abdominal writhes
and increase the latency time to thermal stimuli in both tail
immersion and hot plate tests, similar to standard drug. These
results showed that the ethanolic extract of Caralluma
edulis possesses anti-nociceptive property. Keywords: Anti-nociceptive;
Asclepiadaceae; Caralluma edulis ABSTRAK Penyelidikan ini bertujuan
untuk menilai
kandungan fitokimia dan kesan analgesik
Caralluma edulis (Ce.Cr). Kaedah sedia ada digunakan untuk menganalisis fitokimia tumbuhan. Aktiviti anti-nosiseptik Ce.Cr
diteliti dengan
menggunakan kaedah asid asetik bergelut,
rendaman hujung
dan plat panas. Ce.Cr diuji positif untuk
kehadiran metabolit
terapeutik aktif seperti alkaloid, flavonoid, glikosida,
fenol, tanin,
terpenoid dan saponin.
Ce.Cr pada
dos 10, 30 dan 100 mg/kg merencat abdomen bergelut teraruh asid asetik dan
meningkatkan masa kependaman
untuk rangsangan
terma dalam ujian
rendaman hujung
dan plat panas seperti piawai dadah. Keputusan ini menunjukkan
bahawa ekstrak
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