Sains Malaysiana 46(2)(2017): 245–254

http://dx.doi.org/10.17576/jsm-2017-4602-09

Mood, Cognitive Function and Quality of Life Improvements in Middle Aged Women Following Supplementation with Polygonum minus Extract

(Penambahbaikan Mood dan Kualiti Kehidupan dalam Kalangan Wanita Pertengahan

Umur Selepas Pemberian Ekstrak Polygonum minus)

HANIS MASTURA YAHYA¹*, SUZANA SHAHAR², SITI NUR ARINA ISMAIL¹, AINOR FARAHIN AZIZ¹, NORMAH CHE DIN³ & BIBI NABIHAH ABDUL HAKIM²

¹Nutritional Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences

Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur,

Wilayah Persekutuan, Malaysia

²Dietetics Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Wilayah Persekutuan

Malaysia

³Health Psychology Programme, School of Healthcare Sciences, Faculty of Health Sciences

Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Wilayah Persekutuan, Malaysia

Received: 4 December 2015/Accepted: 8 June 2016

ABSTRACT

Polygonum minus is a plant rich in flavonoids and antioxidants beneficial for reducing oxidative stress and lipid peroxidation in neuronal membranes. This randomized, double-blind, placebo-controlled study evaluated the potential benefits of P. minus extract (LineMinusTM) towards improving cognitive function, mood status and quality of life. Thirty five middle-aged women (35-55 years old) were randomized into intervention (n=17) and control group (n=18). Two capsules of P. minus (250 mg) or placebo (100 mg maltodextrin) each were taken once daily for six weeks. Cognitive tests, mood and anthropometric measurements were measured at baseline, week 3 and week 6, whilst biomarkers were measured at baseline and week 6. Parameters related to mood and quality of life including energy/fatigue, social functioning and general health significantly improved from baseline to week 6 in the intervention group (p<0.05). Mean score for cognitive tests (i.e. digit span, comprehensive trail making test (CTMT) and three domains of CNS vital sign (CNSVS)] improved significantly in both intervention and control groups (p<0.05). There was a significant decrease of mean uric acid, estimated glomerular filtration rate (eGFR), total cholesterol and glycated hemoglobin (HbA1C) in the intervention group from baseline to week 6. P. minus supplementation has the potential to improve mood and quality of life and no adverse effects were reported by the participants after 6 weeks supplementation.

Keywords: Flavonoid; mood; Polygonum minus; phytochemicals; quality of life; supplement

ABSTRAK

Polygonum minus adalah tumbuhan yang kaya dengan flavonoid dan antioksidan serta bermanfaat untuk mengurangkan tekanan oksidatif dan peroksidasi lipid pada membran neuron. Kajian ini berbentuk rawak, dwi-buta dan plasebo-terkawal untuk menilai potensi faedah ekstrak P. minus (LineMinusTM) dalam meningkatkan fungsi kognitif, status mood dan kualiti hidup. Tiga puluh lima wanita pertengahan umur (berumur 35-55 tahun) dibahagikan secara rawak ke dalam kumpulan intervensi (n=17) dan kumpulan kawalan (n=18). Dua kapsul P. minus (250 mg) atau plasebo (100 mg maltodekstrin) telah diambil setiap sehari selama enam minggu. Ujian kognitif, mood dan beberapa ukuran antropometri telah diukur pada peringkat dasar, minggu 3 dan minggu 6, manakala penanda biologi diukur pada peringkat dasar dan minggu 6. Parameter yang berkaitan dengan mood dan kualiti hidup termasuk tenaga/keletihan, fungsi sosial dan kesihatan meningkat secara signifikan pada peringkat dasar hingga minggu 6 untuk kumpulan intervensi (p<0.05). Min skor untuk ujian kognitif seperti Digit Span, Comprehensive Trail Making Test (CTMT) dan tiga domain CNS Vital Sign (CNSVS)] meningkat secara signifikan dalam kedua-dua kumpulan intervensi dan kawalan (p<0.05). Terdapat penurunan yang signifikan dalam min asid urik, anggaran kadar penapisan glomerular (EGFR), jumlah kolesterol dan hemoglobin glycated (HbA1C) dalam kumpulan intervensi pada peringkat dasar dan minggu 6. Pemberian P. minus mempunyai potensi untuk memperbaik mood dan kualiti hidup serta tiada kesan buruk dilaporkan oleh peserta selepas pengambilan selama 6 minggu.

Kata kunci: Fitokimia; flavonoid; kualiti hidup; mood; Polygonum minus; suplemen

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*Corresponding author; email: hanis.yahya@ukm.edu.my