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Sains Malaysiana 46(4)(2017): 559–565 http://dx.doi.org/10.17576/jsm-2017-4604-07
Survival Study and Prognostic
Factors of Ovarian Cancer Registered in a Teaching Hospital in Malaysia (Kajian Mengenai Kelangsungan
Hidup dan Faktor Prognostik bagi Kanser Ovari yang Berdaftar di
Hospital Pelatih Perubatan di Malaysia) NAJIHAH
LOKMAN*,
SITI
AZRIN
AB.
HAMID
& NORSA’ADAH BACHOK Unit
of Biostatistics and Research Methodology, School of Medical Science,
Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim,
Malaysia Received:
20 April 2016/Accepted: 13 September 2016 ABSTRACT Ovarian cancer is one
of the highest causes of death among female population in Malaysia.
A retrospective cohort study among 127 ovarian cancer patients registered
in one of the teaching hospital in Malaysia was conducted from 1st
January 2002 until 31st December 2011. The objective of this study
was to determine the median survival time, five year survival probability
and prognostic factors of ovarian cancer patients. Only ovarian
cancer patients were selected with strict inclusion and exclusion
criteria. Data was analyzed using Kaplan-Meier Survival analysis
and Cox proportional hazard regression analysis. The results showed
that the overall five-year survival probability of ovarian cancer
was 35.2% (95%CI: 26.3, 44.3) with 38 month (95%CI: 25.7, 50.1)
median survival time. After adjustment for potential cofounder,
significant prognostic factors of ovarian cancer were observed in
FIGO stage (HR:
2.53; 1.44, 4.45), loss of appetite (HR: 1.95; 1.23, 3.11) and presence
of pleural effusion (HR: 1.98; 1.19, 3.30). Overall,
the survival probabilities of ovarian cancer were low and further
actions must be taken to improve the survival among advanced cancer
patients Keywords: Median survival
time; ovarian cancer; prognostic factors; survival probability ABSTRAK Kanser ovari merupakan
salah satu penyebab utama yang membawa kepada kematian dalam kalangan
populasi wanita di Malaysia. Satu kajian kohort retrospektif dalam
kalangan 127 orang pesakit kanser ovari yang berdaftar di salah
sebuah hospital pelatih perubatan di Malaysia telah dijalankan dari
1 Januari 2002 sehingga 31 Disember 2011. Objektif kajian ini adalah
untuk mengkaji mengenai tempoh median kelangsungan hidup, keberangkalian
kelangsungan hidup untuk lima tahun dan faktor prognostik bagi pesakit
kanser ovari. Hanya pesakit kanser ovari dipilih berdasarkan kriteria
rangkuman dan penyisihan yang ketat. Data kajian ini dianalisis
menggunakan analisis ‘Kaplan-Meier Survival’ dan analisis regresi
bahaya berkadaran Cox. Hasil kajian ini menunjukkan bahawa keseluruhan
lima tahun kebarangkalian kelangsungan hidup bagi pesakit kanser
ovari adalah 35.2% (95%SK: 26.3, 44.3) dengan median kelangsungan
hidup selama 38 bulan (95%SK: 25.7, 50.1). Selepas penyesuaian untuk
potensi pengasas bersama, faktor prognostik bererti kanser ovari
telah diperhatikan pada tahap FIGO (NB:
2.53; 1.44, 4.45), kurang selera makan (HR: 1.95; 1.23, 3.11) dan kehadiran
pleural efusi (NB: 1.98; 1.19, 3.30). Secara keseluruhannya,
kebarangkalian kelangsungan hidup bagi pesakit kanser ovari di Malaysia
adalah rendah dan tindakan selanjutnya mesti dilakukan untuk meningkatkan
kelangsungan hidup dalam kalangan pesakit kanser kronik. Kata kunci: Faktor prognostik;
kanser ovari; kebarangkalian kelangsungan hidup; median kelangsungan
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