 |
 |
 |
 |
 |
 |
Sains Malaysiana 47(10)(2018):
2359–2368 http://dx.doi.org/10.17576/jsm-2018-4710-12
Piper sarmentosum as an Antioxidant: A Systematic Review (Piper sarmentosum sebagai Antioksidan: Ulasan Sistematik) SITI
MARJIANA
ISMAIL1,2, CHUA KIEN
HUI1,
AMILIA
AMINUDDIN1
& AZIZAH UGUSMAN1* 1Department of Physiology, Faculty
of Medicine, Universiti Kebangsaan
Malaysia Medical Centre, Jalan Yaacob
Latiff, Bandar Tun
Razak, 56000 Cheras, Kuala Lumpur,
Federal Territory, Malaysia 2Institute of Biological Sciences,
Faculty of Science, University of Malaya, 50603 Kuala Lumpur,
Malaysia Received:
31 March 2018/Accepted: 5 June 2018 ABSTRACT Piper sarmentosum
(PS) is an herb with various medicinal properties. The antioxidant
activity of PS contributes to
many of its pharmacological effects such as anti-hypertension,
anti-cancer and anti-diabetes. This systematic review provides
information regarding the antioxidant activity of PS. The review was conducted systematically
to identify relevant published articles on the antioxidant activity
of PS. The collected data was based on the searched articles
through PubMed, Science Direct and Scopus databases between the
years 1946 until March 2018. Only articles written in English
and related to antioxidant activity of PS were included in this review. Based on the literature
searched, 130 potential articles were identified and 19 articles
met the inclusion criteria. Ten studies related to chemical assays,
five studies combined in vivo animal and chemical assays,
three studies combined chemical assays and in vitro studies
and a single study combined chemical assay, in vitro and
in vivo studies were included in this review. All studies
showed positive effects of PS against
oxidation, indicating the potential of PS as a source of natural antioxidant. Keywords: Antioxidant;
free radicals; free radical scavenging effect; oxidative stress;
Piper sarmentosum ABSTRAK Piper
sarmentosum (PS)
merupakan sejenis herba yang mempunyai pelbagai manfaat daripada segi perubatan. Aktiviti antioksidan PS banyak menyumbang kepada kesan farmakologinya
seperti anti-hipertensi,
anti-kanser dan
anti-diabetes. Ulasan sistematik
ini menyediakan
maklumat berkenaan aktiviti antioksidan PS.
Ulasan dilakukan
secara sistematik untuk mengenal pasti penerbitan yang berkaitan dengan aktiviti antioksidan PS.
Data yang dikumpul adalah
berdasarkan artikel yang dicari melalui pangkalan data PubMed, Science Direct dan
Scopus antara tahun
1946 sehingga Mac 2018. Artikel berbahasa Inggeris
yang berkaitan dengan
aktiviti antioksidan PS
dimasukkan ke dalam
ulasan ini.
Berdasarkan pencarian, sebanyak 130 artikel yang berpotensi telah dikenal pasti
dan 19 artikel
memenuhi kriteria inklusif kajian. Sebanyak sepuluh kajian asai kimia,
lima kajian gabungan
kajian asai kimia
dan kajian
in vivo, tiga kajian
gabungan kajian
asai kimia dan
kajian in vitro dan
satu kajian
hasil gabungan asai kimia, kajian
in vivo dan kajian
in vitro terpilih di dalam ulasan ini.
Kesemua
kajian menunjukkan kesan positif PS terhadap pengoksidaan dan ini menandakan
PS
berpotensi sebagai
sumber antioksidan
semula jadi. Kata kunci: Antioksidan; kesan pengaruh radikal bebas; Piper sarmentosum; radikal bebas; stres oksidatif REFERENCES Abd Jalil, M.A., Shuid,
A.N. & Muhammad, N. 2012. Role
of medicinal plants and natural products on osteoporotic fracture
healing. Evidence-based Complementary and Alternative
Medicine 2012: 714512. Amran, A.A., Zakaria, Z., Othman, F., Das, S., Al-Mekhlafi,
H.M. & Nordin, N.A.M. 2011. Changes
in the vascular cell adhesion molecule-1, intercellular adhesion
molecule-1 and c-reactive protein following administration of aqueous extract
of piper sarmentosum on experimental
rabbits fed with cholesterol diet. Lipids in Health and Disease
10: 2. https://doi.org/10.1186/1476-511X-10-2. Amran, A.A., Zakaria, Z., Othman, F., Das, S., Raj, S. & Nordin, N.M.M. 2010. Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high
cholesterolemic experimental rabbits. Lipids in Health
and Disease 9: 44. Ariffin, S.H.Z.,
Omar, W.H.H.W., Ariffin, Z.Z., Safian, M.F., Senafi, S. & Wahab, R.M.A. 2009. Intrinsic anticarcinogenic
effects of Piper sarmentosum ethanolic extract on a human hepatoma cell line. Cancer
Cell International 9(1): 6. Arts,
I.C. & Hollman, P.C. 2005. Polyphenols and disease risk in epidemiologic studies.
The American Journal of Clinical Nutrition 81(1): 317S-325S.
Arunrat, C.,
Piya, M., Runglawan
S. & Tawatchai T. 2006. Ethnobotany
of the Genus Piper (Piperaceae) in Thailand.
Ethnobotany Research & Applications 4: 223-231. Ashokkumar, P.
& Sudhandiran, G. 2008. Protective
role of luteolin on the status of lipid
peroxidation and antioxidant defense against azoxymethane-induced
experimental colon carcinogenesis. Biomedicine &
Pharmacotherapy 62(9): 590-597. Azlina, M.F.N.,
Kamisah, Y., Rahman, R.F.A. & Faizah, O. 2011. Piper Sarmentosum
roxb protects lungs against oxidative
stress induced by carbon tetrachloride in rats. Journal of
Medicinal Plant Research 5(26): 6128-6135. Chan, E.S., Yim, Z.H., Phan, S.H., Mansa, R.F. & Ravindra, P. 2010. Encapsulation of herbal
aqueous extract through absorption with ca-alginate hydrogel beads.
Food and Bioproducts Processing 88(2-3):
195-201. Chanwitheesuk, A.,
Teerawutgulrag, A. & Rakariyatham,
N. 2005.
Screening of antioxidant activity and antioxidant compounds of
some edible plants of Thailand. Food Chemistry 92(3): 491-497.
Clark,
J.L., Zahradka, P. & Taylor, C.G.
2015. Efficacy
of flavonoids in the management of high blood pressure.
Nutrition Reviews 73(12): 799-822. Deetae, P.,
Parichanon, P., Trakunleewatthana,
P., Chanseetis, C. & Lertsiri,
S. 2012.
Antioxidant and anti-glycation properties of
Thai herbal teas in comparison with conventional teas.
Food Chemistry 133(3): 953-959. Del
Rio, D., Stewart, A.J. & Pellegrini, N. 2005. A
review of recent studies on malondialdehyde
as toxic molecule and biological marker of oxidative stress.
Nutrition, Metabolism and Cardiovascular Diseases 15(4):
316-328. Druzynska, B.,
Stępniewska, A. & Wołosiak,
R. 2007.
The influence of time and type of solvent on efficiency of the
extraction of polyphenols from green tea and antioxidant properties
obtained extracts. ACTA Scientiarum
Polonorum Technologia Alimentaria 6(1):
27-36. Hafizah, A.H., Zaiton, Z., Zulkhairi, A., Mohd Ilham, A., Nor Anita, M.M.N. & Zaleha, A.M.
2010. Piper Sarmentosum as an
antioxidant on oxidative stress in human umbilical vein endothelial
cells induced by hydrogen peroxide. Journal of Zhejiang University:
Science B 11(5): 357-365. Hussain,
K., Hashmi, F.K., Latif, A., Ismail, Z. & Sadikun,
A. 2012.
A review of the literature and latest advances
in research of Piper sarmentosum.
Pharmaceutical Biology 50(8): 1045-1052. Hussain, K., Ismail,
Z., Sadikun, A. & Ibrahim, P. 2009.
Antioxidant, anti-tb activities, phenolic
and amide contents of standardised extracts
of Piper Sarmentosum Roxb.
Natural Product Research 23(3): 238-249. Hussain, K., Ismail,
Z., Sadikun, A. & Ibrahim, P. 2010.
Standardization and in vivo antioxidant activity of ethanol
extracts of fruit and leaf of Piper Sarmentosum.
Planta Medica 76(5): 418-425.
Hussan, F.,
Mat Zin, N.N., Zullkefli, M.R., Choon, Y.S., Abdullah, N.A. & Lin, T.S. 2013. Piper Sarmentosum water extract attenuates diabetic complications
in streptozotocin induced Sprague-Dawley
rats. Sains Malaysiana 42(11): 1605-1612. Hutadilok, T.N.,
Chaiyamutti, P., Panthong,
K., Mahabusarakam, W. & Rukachaisirikul,
V. 2006.
Antioxidative and free radical scavenging activities of some plants used in Thai
folk medicine. Pharmaceutical Biology 44(3): 221-228.
Lee,
J.H., Cho, S., Paik, H.D., Choi, C.W., Nam, K.T., Hwang, S.G.
& Kim, S.K. 2014.
Investigation on antibacterial and antioxidant activities, phenolic
and flavonoid contents of some Thai edible plants as an alternative
for antibiotics. Asian-Australasian Journal of Animal Sciences
27(10): 1461-1468. Lee,
K.H., Padzil, A.M., Syahida,
A., Abdullah, N., Zuhainis, S.W., Maziah,
M., Sulaiman, M.R., Israf,
D.A., Shaari, K. & Lajis,
N.H. 2011.
Evaluation of Anti-inflammatory, antioxidant
and antinociceptive activities of six Malaysian medicinal plants.
Journal of Medicinal Plant Research 5(23): 5555-5563. Marxen, K., Vanselow, K.H., Lippemeier, S.,
Hintze, R., Ruser, A. & Hansen,
U.P. 2007. Determination of DPPH radical oxidation caused by methanolic extracts of some microalgal
species by linear regression analysis of spectrophotometric measurements.
Sensors 7(10): 2080-2095. Miean, K.H. & Mohamed,
S. 2001. Flavonoid (myricetin,
quercetin, kaempferol, luteolin,
and apigenin) content of edible tropical
plants. Journal of Agricultural and Food Chemistry 49(6):
3106-3112. Mohd, Z.M., Zakaria,
Z. & Megat Mohd
Nordin, N.A. 2015. The use of Piper Sarmentosum
leaves aqueous extract (Kadukmy™)
as antihypertensive agent in spontaneous hypertensive rats. BMC
Complementary and Alternative Medicine 15: 54. https://doi.org/10.1186/s12906-015-0565-z.
Moher,
D., Shamseer, L., Clarke, M., Ghersi,
D., Liberati, A., Petticrew,
M., Shekelle, P. & Stewart, L.A.
2015. Preferred
reporting items for systematic review and meta-analysis protocols
(PRISMA-P) 2015 statement. Systematic Reviews 4(1):
1. Nur Syamsina
Ahmad, Azlina Abdul Aziz, Kin Weng
Kong, Mohamad Shariff A. Hamid, Jadeera
Phaik Geok
Cheong & Sareena Hanim Hamzah.
2017. Dose response effect of tualang
honey on postprandial antioxidant activity and oxidative stress
in female athletes: A pilot study. The Journal of Alternative
and Complementary Medicine 23(12): 989-995. Olaleye, M.,
Crown, O., Akinmoladun, A. & Akindahunsi, A. 2014. Rutin
and quercetin show greater efficacy than nifedipin
in ameliorating hemodynamic, redox, and metabolite imbalances
in sodium chloride-induced hypertensive rats. Human & Experimental
Toxicology 33(6): 602-608. Perez-Jimenez,
J. & Saura-Calixto, F. 2006. Effect
of solvent and certain food constituents on different antioxidant
capacity assays. Food Research International 39(7):
791-800. Rahman,
S.F.S.A., Sijam, K. & Omar, D. 2016. Piper sarmentosum Roxb.: A mini review of ethnobotany, phytochemistry
and pharmacology. Journal of Analytical & Pharmaceutical
Research 2(5): 00031. Ren,
B., Qin, W., Wu, F., Wang, S., Pan, C., Wang, L., Zeng, B., Ma,
S. & Liang, J. 2016. Apigenin and
naringenin regulate glucose and lipid
metabolism, and ameliorate vascular dysfunction in type 2 diabetic
rats. European Journal of Pharmacology 773: 13-23. Renugadevi, J. & Prabu, S.M. 2010. Cadmium-induced hepatotoxicity in rats and
the protective effect of naringenin.
Experimental and Toxicologic Pathology
62(2): 171-181. Rubio,
C.P., Hernandez-Ruiz, J., Martinez-Subiela,
S., Tvarijonaviciute, A. & Ceron,
J.J. 2016. Spectrophotometric assays for total antioxidant capacity
(tac) in dog serum: An update. BMC Veterinary Research 12(1):
166. Sies, H. 1997. Oxidative
stress: Oxidants and antioxidants. Experimental physiology
82(2): 291-295. Subramaniam,
V., Adenan, M.I., Ahmad, A.R. &
Sahdan, R. 2003. Natural antioxidants:
Piper Sarmentosum (Kadok) and Morinda Elliptica (Mengkudu). Malaysian
Journal of Nutrition 9(1): 41-51. Sulaiman,
S.F., Sajak, A.A.B., Ooi,
K.L., Supriatno & Seow,
E.M. 2011. Effect of solvents in extracting polyphenols and antioxidants
of selected raw vegetables. Journal of Food Composition and
Analysis 24(4): 506-515. Sumazian,
Y., Syahida, A., Hakiman,
M. & Maziah, M. 2010. Antioxidant activities, flavonoids, ascorbic acid and phenolic contents
of Malaysian vegetables. Journal of Medicinal Plants
Research 4(10): 881-890. Tang, Z., Li, M., Zhang, X. & Hou, W. 2016. Dietary flavonoid
intake and the risk of stroke: A dose-response meta-analysis of
prospective cohort studies. BMJ Open 6(6): e008680. Ugusman,
A., Zakaria, Z., Chua, K., Nordin, N.M.M.
& Mahdy, Z.A. 2012. Flavanoids of Piper
sarmentosum and its cytoprotective
effects against oxidative stress. EXCLI Journal 11:
705-714. Ugusman, A., Zakaria,
Z., Hui, C.K. & Megat Mohd
Nordin, N.A. 2011. Piper sarmentosum
inhibits ICAM-1 and NOX4 gene expression in oxidative stress-induced
human umbilical vein endothelial cells. BMC Complementary and
Alternative Medicine 2011: 11. https://doi.org/10.1186/1472-6882-11-31.
Velioglu, Y., Mazza, G., Gao, L. & Oomah, B. 1998. Antioxidant activity and
total phenolics in selected fruits,
vegetables, and grain products. Journal of Agricultural
and Food Chemistry 46(10): 4113-4117. Wan Ibrahim, W.I., Sidik,
K. & Kuppusamy, U.R. 2010. A high
antioxidant level in edible plants is associated with genotoxic
properties. Food Chemistry 122(4): 1139-1144. Wang, D.F., Zhou, L.L., Zhou, H.L., Hou, G.Y., Zhou, X. & Li, W. 2017. Effects
of Piper sarmentosum extract
on the growth performance, antioxidant capability and immune response
in weaned piglets. Journal of Animal Physiology and Animal
Nutrition 101(1): 105-112. Wongsa,
P., Chaiwarit, J. & Zamaludien,
A. 2012. In vitro screening of phenolic
compounds, potential inhibition against α-amylase and α-glucosidase
of culinary herbs in Thailand. Food Chemistry 131(3):
964-971. Yeo, E.T.Y., Wong, K.W.L., See, M.L., Wong,
K.Y., Gan, S.Y. & Chan, E.W.L. 2018. Piper sarmentosum Roxb. confers neuroprotection
on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation
in SH-SY5Y cells. Journal of Ethnopharmacology
217: 187-194. *Corresponding author; email: dr.azizah@ppukm.ukm.edu.my
|
|||
|
