Sains Malaysiana 47(10)(2018): 2455–2461

http://dx.doi.org/10.17576/jsm-2018-4710-22

 

Association between Pulse Wave Velocity with Other Vascular Markers and Inflammation among Young Adults: An Evidence-Based Review

(Perkaitan antara Halaju Gelombang Nadi dengan Penanda Vaskular Lain dan Inflamasi dalam Kalangan Orang Muda: Satu Penilaian Berasaskan Bukti)

 

NORIZAM SALAMT, AMILIA AMINUDDIN*, AZIZAH UGUSMAN & AINI FARZANA ZULKEFLI

 

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

Received: 30 March 2018/Accepted: 20 June 2018

 

ABSTRACT

Studies evaluating the association between pulse wave velocity (PWV), a gold standard measurement of aortic stiffness and established markers of cardiovascular disease (CVD), with other established vascular markers or inflammation among young adult is still scarce. A systematic review of the literature was conducted to identify relevant studies on the association between PWV with other vascular markers or inflammation. Relevant articles from Ovid Medline, Science Direct and Scopus databases were explored between 2009 and March 2018. Original articles published in English measuring any correlation between carotid-femoral PWV (PWVcf) with either augmentation index (AIx), carotid intima media thickness (CIMT) or C-reactive protein (CRP) on young adult with age range between 18 and 45 years old were included. The literature search identified 21 potential articles to be reviewed, which meet all the inclusion criteria. Four articles investigated the correlation between PWVcf with CRP, however only two studies gave significant but weak correlations. As for CIMT, a single relevant article was found and the correlation was not significant. In conclusion, lack of association between PWV and other vascular markers and inflammation may suggest that these vascular markers have their own property in assessing vascular status. Thus, these markers should be measured independently for comprehensive assessment of future CVD risk.

 

Keywords: Carotid-femoral pulse wave velocity; inflammation; vascular stiffness; young adults

 

ABSTRAK

Halaju gelombang nadi (PWV) merupakan satu pengukuran piawai kekakuan aorta dan merupakan penanda terkenal penyakit kardiovaskular (CVD). Namun, kajian yang menilai hubungan antara PWV dengan penanda vaskular terkenal yang lain dan inflamasi masih terhad. Sorotan kajian yang sistematik telah dijalankan bagi mengenal pasti kajian yang mengukur hubungan antara PWV dengan penanda vaskular lain atau inflamasi. Pangkalan data Ovid Medline, Science Direct dan Scopus digunakan untuk mencari artikel berkaitan yang diterbitkan dari tahun 2009 sehingga Mac 2018. Hanya artikel asal yang diterbitkan dalam bahasa Inggeris dan mengukur sebarang korelasi antara PWV karotid-femoral (PWVcf) dengan indeks augmentasi (AIx), ketebalan intima media arteri karotid (CIMT) atau protein C-reaktif (CRP) ke atas populasi muda dengan julat umur 18 hingga 45 tahun diterima. Terdapat 21 makalah yang memenuhi semua kriteria kemasukan dan layak untuk dikaji dan dinilai. Empat artikel mengkaji hubungan antara PWVcf dengan CRP, namun hanya dua kajian menunjukkan hubungan yang signifikan namun lemah. Untuk CIMT, satu kajian yang berkaitan telah didapati dan hubungannya dengan PWV adalah tidak signifikan. Kesimpulannya, kekurangan hubungan antara PWV dengan penanda vaskular lain dan inflamasi mungkin menunjukkan setiap penanda vaskular mempunyai sifat tersendiri dalam menilai status vaskular. Sehubungan itu, penanda vaskular tersebut perlu diukur secara berasingan bagi menilai risiko CVD akan datang secara menyeluruh.

 

Kata kunci: Halaju gelombang nadi karotid-femoral; inflamasi; kekakuan vaskular; orang muda

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*Corresponding author; email: amilia@ppukm.ukm.edu.my