Sains Malaysiana 47(2)(2018): 319-322

http://dx.doi.org/10.17576/jsm-2018-4702-14

Chabrolene, a Novel Norditerpene from the Bornean Soft Coral Nephthea sp.

(Chabrolene, Sebatian Novel Norditerpene daripada Karang Lembut Bornean Nephthea sp.)

Takahiro Ishii, Takashi Kamada, Chin-Soon Phan & Charles S. Vairappan*

Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah

88400 Kota Kinabalu, Sabah, Malaysia

Received: 6 July 2017/Accepted: 7 September 2017

ABSTRACT

Soft corals are often the research interest organism due to their structural diverse secondary metabolites with wide spectrum of biological activities range from antibacterial to anticancer potentials. The Borneo Island is rich in diversity of marine organisms including soft coral. Therefore, a population of Bornean soft coral belongs to genus Nephthea was collected from Mantanani Island (Sabah, Malaysia) which led to the isolation of a novel norditerpene, chabrolene (1) together with three known compounds (2-4). The chemical structure of 1 was determined by NMR and HREIMS data. Compound 1 exhibited repellent activity against the maize weevil Sitophilus zeamais.

Keywords: Nephthea sp.; norditerpene; repellent activity; Sitophilus zeamais; soft coral

ABSTRAK

Karang lembut sering dikenali sebagai organisma yang penting dalam penyelidikan disebabkan oleh metabolit sekunder yang pelbagai struktur. Selain itu, ia juga mempunyai pelbagai aktiviti biologi terdiri daripada potensi antibakteria hingga anti-kanser. Pulau Borneo kaya dengan kepelbagaian organisma marin termasuk karang lembut. Oleh itu, satu populasi karang lembut Bornean genus Nephthea dikumpulkan dari Pulau Mantanani (Sabah, Malaysia) dan mendapati satu norditerpene baru, chabrolene (1) dan tiga sebatian yang telah dikenal pasti (2-4). Struktur kimia untuk keempat-empat sebatian ini dikenal pasti berdasarkan analisis data spektroskopi NMR dan HREIMS. Sebatian 1 didapati mempunyai aktiviti penolak terhadap kutu jagung Sitophilus zeamais.

Kata kunci: Aktiviti penolak; karang lembut; Nephthea sp.; norditerpene; Sitophilus zeamais

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*Corresponding author; email: csv@ums.edu.my