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http://dx.doi.org/10.17576/jsm-2018-4707-26
Keratitis Acanthamoeba di Malaysia
(Acanthamoeba Keratitis in Malaysia)
MOHAMED KAMEL ABD GHAN1I*, IRDAWATI AZHAR1, HALIZA ABDUL MUTALIB1,
ANISAH NORDIN2, YUSOF SUBOH2, NORAINA AB RAHIM2 & NORAZAH AHMAD3
1Fakulti Sains Kesihatan,
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur,
Wilayah Persekutuan, Malaysia
2Fakulti Perubatan, Universiti
Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur,
Wilayah Persekutuan, Malaysia
3Institut Penyelidikan
Perubatan, Jalan Pahang, 50588 Kuala Lumpur, Wilayah Persekutuan, Malaysia
Received: 21 September 2017/Accepted: 12
February 2018
ABSTRAK
Acanthamoeba spp. merupakan
ameba hidup bebas yang tersebar luas di persekitaran. Ameba ini
menyebabkan penyakit keratitis terutamanya kepada individu yang
memakai kanta sentuh terkontaminasi atau mempunyai sejarah trauma
pada mata. Tujuh puluh empat sampel kikisan kornea pesakit keratitis
daripada 4 buah hospital di sekitar Lembah Kelang telah dikultur
untuk menemukan Acanthamoeba spp. Keputusan kajian mendapati
Acanthamoeba spp. berjaya dipencilkan daripada 14.87% sampel
kikisan kornea pesakit keratitis. Berdasarkan kajian ini, kesemua
pesakit keratitis Acanthamoeba adalah merupakan pemakai kanta
sentuh yang majoritinya (90.9%) terdiri daripada kaum wanita. Kanta
sentuh lembut terlibat dalam 90.9% kes manakala jenis kanta separa
keras cuma satu kes 9.1%. Kesemua 11 pencilan Acanthamoeba yang
dipencilkan adalah daripada kumpulan polyphagids yang biasanya patogenik
kepada manusia dan menyebabkan jangkitan ini. Kegagalan pengguna
kanta sentuh mengamalkan tahap kebersihan kanta sentuh yang baik
merupakan faktor risiko yang penting dalam kejadian keratitis Acanthamoeba
di Malaysia.
Kata kunci: Acanthamoeba;
kanta sentuh; keratitis; Malaysia
ABSTRACT
Acanthamoeba spp. are ubiquitous
free-living amoebae that are commonly found in environment. It may
cause keratitis in individual using contaminated contact lens or
having history of ocular trauma. Seventy-four samples of corneal
scrapings from keratitis patients, from 4 hospitals in Klang Valley
were cultured for the isolation of Acanthamoeba. Acanthamoeba
spp. were successfully isolated from 14.87% of corneal scraping
samples from keratitis patients. This study showed that all of the
Acanthamoeba keratitis patients were contact lens wearers
majority of whom were women (90.9%). Soft contact lens were implicated
in 90.9% of cases while the rigid gas permeable type in only one
case (9.1%). All 11 Acanthamoeba isolates were from the polyphagids
group which were known to be pathogenic to human. Failure of contact
lens users to practice good hygienic care of their lenses attributed
to the risk factor for the occurrence of Acanthamoeba keratitis
in Malaysia.
Keywords: Acanthamoeba;
contact lens; keratitis; Malaysia
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*Corresponding author; email: profkamel@ukm.edu.my
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