Sains Malaysiana 48(6)(2019): 1301–1310

http://dx.doi.org/10.17576/jsm-2019-4806-19

Recent Progress on Fabrication of Zinc Oxide Nanorod-Based Field Effect Transistor Biosensors

(Kemajuan Terkini Fabrikasi Biosensor Berasaskan Nanorod Kesan Medan Transistor Zink Oksida)

SITI SHAFURA A KARIM, CHANG-FU DEE, BURHANUDDIN YEOP MAJLIS & MOHD AMBRI MOHAMED*

Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia,43600 UKM Bangi, Selangor Darul Ehsan, Malaysia

Received: 20 February 2019/Accepted: 19 March 2019

ABSTRACT

Zinc oxide is a unique n-type semiconducting material, owing to wide bandgap of ~3.37 eV, non-toxic, bio-safe and biocompatible with high isoelectric point of ~9.5, make it as promising biomaterial to be utilized as sensing matrix in biosensor applications. In addition, ZnO that possess high electron affinity provide a good conduction pathway for the electrons hence result in significant electrical signal change upon detection to target biomolecules. Moreover, high surface area of ZnO nanorod enhance immobilization of enzymes, hence, increase the device performance. Field effect transistor (FET)-based biosensor offer simplicity in handling and label-free, has also become research topic among researchers for novel biosensor development. This review aims to explore the preparation of ZnO nanorod using hydrothermal method and investigate the fabrication of ZnO nanorod-based FET biosensor. Thus, contribute to enhance understanding towards biosensor development for health monitoring, especially based on FETs structure devices.

Keywords: Biosensor; field effect transistor; hydrothermal method; zinc oxide nanorod

ABSTRAK

Zink oksida adalah bahan semikonduktor jenis-n yang unik, disebabkan oleh ketinggian selebar ~3.37 eV, tidak toksik, selamat dan bioserasi dengan titik isoelektrik yang tinggi ~9.5, menjadikan ia sebagai biobahan yang sesuai digunakan sebagai matriks penderia dalam aplikasi biosensor. Di samping itu, ZnO yang mempunyai keafinan elektron yang tinggi memberikan laluan konduksi yang baik untuk elektron dan mengakibatkan perubahan isyarat elektrik yang signifikan apabila pengesanan kepada biomolekul sasaran. Tambahan pula, kawasan permukaan ZnO nanorod yang tinggi meningkatkan immobilisasi enzim, seterusnya meningkatkan prestasi peranti. Biosensor berasaskan kesan medan transistor (FET) adalah mudah dikendalikan dan bebas label, juga menjadi topik penyelidikan dalam kalangan penyelidik untuk pembangunan biosensor yang novel. Kajian ini bertujuan untuk meneroka penyediaan ZnO nanorod menggunakan kaedah hidroterma dan mengkaji fabrikasi biosensor FET yang berasaskan ZnO nanorod. Sekaligus menyumbang kepada kefahaman tentang pembangunan biosensor untuk memantau kesihatan, terutamanya yang berasaskan struktur FETs.

Kata kunci: Biosensor; kaedah hidroterma; kesan medan transistor; zink oksida nanorod

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*Corresponding author; email: ambri@ukm.edu.my