Sains Malaysiana 49(2)(2020): 335-341

http://dx.doi.org/10.17576/jsm-2020-4902-11

Umbilical Cord Derived Mesenchymal Stem Cell Therapy for Osteoarthritis: A Consolidated Review

(Tali Pusat Terbitan Terapi Sel Stem Mesenkima untuk Osteoartritis: Suatu Ulasan Lengkap)

JIANWEI ZUO¹, CHEN CHEN², XINTAO ZHANG¹ & WENTAO ZHANG¹*

¹Department of Sports Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, P.R. China

²Department of Anesthesiology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, P.R. China

Received: 22 April 2019/Accepted: 6 November 2019

Abstract

Osteoarthritis (OA) is a leading cause of degenerative disease and is the most common persistent condition worldwide. The common burden imposed by OA significantly damages the articular cartilage, which results in pain and seriously impacts the quality of life in the affected people. Disease progression is assumed to increase with obesity and aging. The current therapies include weight loss, activity adjustment, traditional pain management and replacement of the affected joint. To overcome these limitations, recently, cell-based therapies mainly Umbilical cord derived Mesenchymal stem cell (UC-MSC) have become an attractive cell source for an allogeneic mesenchymal stem cell to repair and regenerate the structure and function of articular tissues. Although the mechanism is not clearly defined, it is believed that the paracrine signaling, inflammatory response, and immunomodulatory role of UC-MSCs play a crucial role in developing a treatment approach of OA. The purpose of this review was to outline the advantages of using UC-MSCs in treating OA. This review also discusses the possible hurdles that stand in the way of successful implementation of UC-MSC as a routine treatment regimen for OA.

Keywords: Allogeneic stem cell; mesenchymal stem cell; osteoarthritis; umbilicalcord tissue

Abstrak 

Osteoartitis (OA) adalah penyebab utama penyakit degeneratif dan merupakan keadaan yang paling biasa di seluruh dunia. Beban umum yang disebabkan oleh OA dengan ketara merosakkan artikul rawan yang mengakibatkan kesakitan dan memberi kesan serius terhadap kualiti hidup orang yang mengalaminya. Janjang penyakit ini dianggap meningkat dengan keobesan dan penuaan. Terapi semasa termasuklah penurunan berat badan, pelarasan aktiviti, pengurusan sakit secara tradisi dan penggantian sendi yang terjejas. Untuk mengatasi keterbatasan ini, terbaru, terapi berasaskan sel terutamanya tali pusat terbitan terapi sel stem mesenkima (UC-MSC) telah menjadi sumber sel yang menarik untuk sel stem alogen mensenkima untuk membaiki dan menjana semula struktur dan fungsi tisu artikul. Walaupun mekanisme itu belum ditakrifkan dengan jelas, dipercayai bahawa isyarat parakrin, tindak balas keradangan dan peranan imunomodul UC-MSC memainkan peranan penting dalam membangunkan pendekatan rawatan OA. Tujuan kajian ini adalah untuk menggariskan kelebihan menggunakan UC-MSC dalam merawat OA. Ulasan ini juga membincangkan kemungkinan halangan yang berlaku dalam pelaksanaan UC-MSC dengan jayanya sebagai regimen rawatan rutin untuk OA.

Kata kunci: Osteoartitis; sel stem alogen; sel stem mesenkima; tisu tali pusat

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*Corresponding author; email: zhangwentao1121@sina.com