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Sains
Malaysiana 49(2)(2020): http://dx.doi.org/10.17576/jsm-2020-4902-20
In vitro Study
of Anti-Helicobacter pylori Activity
of Honey: A Systematic Review
ADAM QURAISIAH1, ANNUAR FAZALDA1,
HANAFIAH ALFIZAH2 & MOHD FAHAMI NUR AZLINA1*
1Department of Pharmacology, Faculty of Medicine, Universiti
Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Federal
Territory, Malaysia
2Department of Medical Microbiology & Immunology, Faculty
of Medicine, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Federal Territory,
Malaysia
Received: 6 May 2019/Accepted: 4 November 2019
ABSTRACT
This review explores the
beneficial effects of honey on Helicobacter pylori-induced gastric ulcer and duodenal ulcer. The research of the effectiveness
of honey on H.
pylori infection
using electronic databases was done, these include Medline via Ovid Medline, Scopus and ScienceDirect published from the year 2000 to
2018. The articles were evaluated and selected based on the criteria
which report on the effects of honey on gastric ulcer and duodenum
ulcer caused by H. pylori infection. There are 53
articles were identified, which stated to the studies that relate
to the criteria. Afterwards, nine articles on honey and its extracts
were selected and assessed accordingly in this review. All studies
reported positive effects of honey on H. pylori-induced gastric ulser
and duodenal ulcer. Most of the studies showed at minimum 10% of
honey concentration were effective as anti-H.
pylori activity. This systematic
review emphasized the potential of honey used to inhibit the H.
pylori infection in-vitro. Future extensive studies are required to find the active component and
molecular mechanism of honey before animal and human observational
studies could be conducted to deliver valid evidence.
Keywords: Duodenal
ulcer; gastric cancer; gastric ulcer; gastritis; Helicobacter pylori; honey
ABSTRAK
Ulasan
ini adalah untuk mengkaji kesan manfaat madu pada Helicobacter
pylori teraruh ulser gaster
dan ulser duodenal. Satu kajian terhadap
keberkesanan madu pada jangkitan H. pylori menggunakan pangkalan data elektronik telah
dilakukan, ini termasuklah Medline melalui Ovid Medline, Scopus
dan ScienceDirect yang telah diterbitkan dari tahun 2000-2018. Artikel
telah dinilai dan dipilih berdasarkan kriteria yang melaporkan mekanisme dan kesan madu pada
ulser gaster dan ulser duodenal yang disebabkan oleh jangkitan H.
pylori. Terdapat 53
artikel telah dikenal pasti yang merujuk kepada kajian yang sepadan dengan
kriteria. Seterusnya, sembilan artikel mengenai madu dan ekstrak
madu telah dipilih dan dinilai sewajarnya dalam kajian ini. Semua
kajian melaporkan kesan positif pada madu terhadap H.
pylori yang berpunca daripada
ulser gastrik dan ulser duodenal. Kebanyakan kajian menunjukkan
sekurang-kurangnya kepekatan madu sebanyak 10% berkesan sebagai
aktiviti anti-H. pylori. Kajian sistematik ini menekankan potensi
madu yang digunakan untuk merencatkan jangkitan H. pylori secara in-vitro. Kajian menyeluruh pada masa akan datang adalah perlu untuk mencari komponen
aktif dan mekanisme molekul yang ada pada madu sebelum kajian pengamatan
terhadap haiwan dan manusia dijalankan untuk memberi bukti yang
sah.
Kata kunci: Gastritis; Helicobacter pylori; kanser gaster; madu; ulser duodenal; ulser
gaster
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*Corresponding
author; email: nurazlinamf@ukm.edu.my
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