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Sains Malaysiana 51(6)(2022):
http://doi.org/10.17576/jsm-2022-5106-11
Study on the Anti-Inflammatory Mechanism of Volatile Components of Hebei Aster tataricus Before and After Honey-Fried Based on Gas Chromatography-Mass Spectrometry and Network Pharmacology
(Kajian Mekanisme Anti-Radang Komponen Meruap Hebei Aster tataricus Sebelum dan Selepas Digoreng dengan Madu Berdasarkan Kromatografi
Gas-Spektrometri Jisim dan Farmakologi Rangkaian)
LIJUAN
LV1, XIANGPEI WANG2, HONGMEI WU1,*, KE
ZHONG1 & FENG XU1
1Department of Pharmacognosy, Guizhou
University of Traditional Chinese Medicine,
Guiyang, Guizhou,
China
2National Medical College, Guizhou Minzu University, Guiyang, Guizhou, China
Received: 27 July
2021/Accepted: 2 November 2021
Abstract
Aster tataricus (AT) and honey-fried Aster tataricus (HAT) have a significant effect on relieving
cough and reducing sputum, both of which contain many volatile components.
Studies have shown that the volatile components of AT and HAT may have an
anti-inflammatory effect, but the mechanism is unclear. This study aimed to
analyze the daodi herb of Hebei AT and HAT
qualitatively and quantitatively using gas chromatography-mass spectrometry and
systematically explored the similarities and differences of anti-inflammatory
molecular mechanisms of volatile components Hebei AT and HAT by using network
pharmacology. These results indicate that there are significant differences in
volatile compositions and percentage contents between AT and HAT. Moreover, the
anti-inflammatory mechanism of volatile components of Hebei AT and HAT have
more prominent similarities and fewer differences. AT and HAT's similar potential active components such as humulene,γ-muurolene,
α-phellandrene,
and acetic acid were nine. The similar key gene targets were forty-seven,
such as CAT, GAPDH, HMOX1, and CTH. The potential active ingredients peculiar
to HAT were furfural, β-elemene, methyleugenol, and unique targets of EIF6 and PKIA. It
suggests that HAT had its characteristics in clinical anti-inflammatory. Their
active anti-inflammatory components and percentage contents were different, and
HAT was higher than that of AT. The anti-inflammatory effect of volatile
components of HAT may be better than that of AT. These results provide a theoretical
basis for the study of the anti-inflammatory molecular mechanism of AT and HAT.
Keywords:
Anti-inflammatory; Aster tataricus;
honey-fried; volatile components
Abstrak
Aster tataricus (AT) dan Aster tataricus (HAT) goreng madu mempunyai kesan yang ketara bagi melegakan batuk dan mengurangkan kahak, kedua-duanya mengandungi banyak komponen yang meruap. Kajian telah menunjukkan bahawa komponen meruap AT dan HAT mungkin mempunyai kesan anti-radang, tetapi mekanismenya tidak jelas. Kajian ini bertujuan untuk menganalisis herba daodi Hebei AT dan HAT secara kualitatif dan kuantitatif menggunakan kromatografi gas-spektrometri jisim dan secara sistematik bagi meneroka persamaan dan perbezaan mekanisme molekul anti-radang komponen meruap Hebei AT dan HAT dengan menggunakan farmakologi rangkaian. Keputusan menunjukkan bahawa terdapat perbezaan yang signifikan dalam komposisi komponen meruap dan kandungan peratusan antara AT dan HAT. Selain itu, mekanisme anti-radang komponen yang meruap pada Hebei AT dan HAT mempunyai lebih banyak persamaan dan hanya sedikit perbezaan. Komponen sama aktif berpotensi AT dan HAT seperti humulena, γ-muurolene,
α-phellandrene dan asid asetik adalah sembilan. Sasaran gen utama yang sama ialah empat puluh tujuh, seperti CAT, GAPDH, HMOX1 dan CTH. Bahan aktif yang berpotensi khusus untuk HAT ialah furfural, β-elemene, metileugenol dan sasaran unik EIF6 dan PKIA. Ia menunjukkan bahawa HAT mempunyai ciri-cirinya dalam anti-radang klinikal. Komponen anti-radang aktif dan kandungan peratusannya berbeza dan HAT lebih tinggi daripada AT. Kesan anti-radang komponen meruap pada HAT lebih baik daripada AT. Keputusan ini memberikan asas teori untuk kajian mekanisme molekul anti-radang AT dan
HAT.
Kata kunci: Anti-radang; Aster tataricus;
goreng madu; komponen yang meruap
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*Corresponding author; email: whm0425@126.com
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