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Sains
Malaysiana 38(6)(2009): 869–872
A Study Towards the Total Synthesis of
TAN1251B
(Kajian
bagi Mensintesis TAN1251B Secara Menyeluruh)
Aznuzilawati Asari*
Department of Chemical Sciences, Faculty
of Science and Technology
Universiti Malaysia Terengganu, 21030
Kuala Terengganu, Malaysia
Christopher J. Hayes
School of Chemistry, University of
Nottingham
University Park, Nottingham NG7 2RD, United Kingdom
Diserahkan: 18 Februari 2009 / Diterima:
20 April 2009
ABSTRACT
A synthetic route towards the
synthesis of TAN1251B was developed utilizing an alkylidene carbene insertion
reaction as a key step to construct the quartenary centre. The α-hydroxylation of the 5,6-spirocyclic enone with
iodosobenzene was successful to give a mixture of diastereomer compounds 20 and
21 in 1:1.2 ratios.
Keywords: TAN1251B; alkylidene
carbene; α-hydroxylation;
iodosobenzene
ABSTRAK
Laluan
sintetik bagi mensintesis sebatian TAN1251B dikembangkan dengan menggunakan
tindak balas penyelitan alkilidin karbena sebagai langkah untuk menjana pusat
kuarterner. Tindak balas penghidroksilan 5,6-spirosiklik enon dengan
iodosobenzena telah berjaya memberikan campuran hasil diastereomer 20 dan 21
dalam nisbah 1:1.2.
Kata kunci: TAN1251B; alkiliden karbena; α-penghidroksilan;
iodosobenzena
RUJUKAN
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*Pengarang untuk surat-menyurat; e-mail: asnu@umt.edu.my
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