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Bacterial Cellulose Film Coating as Drug
Delivery System: Physicochemical,
Thermal and Drug Release Properties
(Penyalutan
Filem Selulosa Bakteria sebagai Satu Sistem Penyampaian Dadah:
Sifat-sifat
Fizikokima, Terma dan Pelepasan Dadah)
Mohd Cairul Iqbal Mohd Amin*, Abadi Gumah Abadi, Naveed Ahmad
Haliza Katas
& Jamia Azdina Jamal
Faculty
of Pharmacy, Universiti
Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz
50300,
Kuala Lumpur, Malaysia
Diserahkan:
21 Julai 2011 / Diterima: 20 Oktober 2011
ABSTRACT
There has been an increasing interest in
the use of natural materials as drug delivery vehicles due to their
biodegradability, biocompatibility and ready availability. These properties
make bacterial cellulose (BC), from nata de coco, a promising biopolymer
for drug delivery applications. The aim of this study was to investigate the
film-coating and drug release properties of this biopolymer. Physicochemical,
morphological and thermal properties of BC films
were studied. Model tablets were film coated with BC, using a
spray coating technique, and in
vitro drug release studies of these tablets were investigated. It
was found that BC exhibited excellent
ability to form soft, flexible and foldable films without the addition of any
plasticizer. They were comparable to Aquacoat ECD (with
plasticizer) in tensile strength, percentage elongation and elasticity modulus.
Differential scanning calorimetry (DSC) BC showed a
high Tg value indicating thermally stability of films.
These results suggest that BC can be used as novel
aqueous film-coating agent with lower cost and better film forming properties
than existing film-coating agents.
Keywords:
Bacterial cellulose; drug delivery; DSC; film-coating; Young’s modulus
ABSTRAK
Penggunaan bahan semula
jadi sebagai satu pendekatan penyampaian dadah semakin mendapat perhatian
disebabkan sifatnya yang bioterurai, bioserasi dan mudah diperoleh. Kepelbagaian sifat ini menjadikan selulosa bakteria (BC)
daripada nata de coco, menjanjikannya
sebagai satu biopolimer untuk aplikasi penyampaian dadah. Kajian ini dilakukan bertujuan untuk menyelidiki sifat penyalutan
filem dan pelepasan dadah biopolimer tersebut. Kajian
fizikokimia, morpologi, dan terma BC telah dilakukan. Penyelidikan ke atas model tablet yang disaluti BC menggunakan
kaedah penyalutan secara semburan dan kajian pelepasan dadah secara in vitro dari tablet telah
dilakukan. Adalah didapati BC menunjukkan
keupayaan yang hebat untuk membentuk filem yang lembut, fleksibel, mudah
dilipat tanpa menambah sebarang bahan pemplastik. Ianya
setanding dengan Aquacoat ECD (dengan bahan pemplastik) daripada
segi kekuatan tensil, peratus pemanjangan dan modulus keelastikan. Pengesanan pembezaan kalorimeter (DSC) BC menunjukkan
satu nilai Tg yang tinggi membuktikan kestabilan
filem secara terma. Hasil keputusan mencadangkan BC boleh
digunakan sebagai agen penyalut filem akues yang baru pada kos yang rendah dan bersifat pembentukan filem lebih baik berbanding agen
penyalutan filem yang sedia ada.
Kata kunci: DSC; modulus Young; penyalutan
filem; penyampaian dadah; selulosa bakteria
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*Pengarang untuk surt-menyurat; email: mciamin@pharmacy.ukm.my
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