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Sains Malaysiana 47(2)(2018):
319-322
http://dx.doi.org/10.17576/jsm-2018-4702-14
Chabrolene, a
Novel Norditerpene from the Bornean Soft Coral Nephthea sp.
(Chabrolene, Sebatian Novel Norditerpene daripada Karang Lembut Bornean Nephthea sp.)
Takahiro Ishii, Takashi
Kamada, Chin-Soon Phan & Charles S. Vairappan*
Institute
for Tropical Biology and Conservation, Universiti Malaysia Sabah
88400
Kota Kinabalu, Sabah, Malaysia
Diserahkan: 6 Julai 2017/Diterima: 7 September 2017
ABSTRACT Soft corals are often the research interest
organism due to their structural diverse secondary metabolites
with wide spectrum of biological activities range from antibacterial
to anticancer potentials. The Borneo Island is rich in diversity
of marine organisms including soft coral. Therefore, a population
of Bornean soft coral belongs to genus Nephthea was collected
from Mantanani Island (Sabah, Malaysia) which led to the isolation
of a novel norditerpene, chabrolene (1) together with three known compounds (2-4). The chemical structure of 1 was determined by NMR and HREIMS data.
Compound 1 exhibited repellent activity against the
maize weevil Sitophilus zeamais.
Keywords: Nephthea sp.; norditerpene;
repellent activity; Sitophilus zeamais; soft coral
ABSTRAK Karang lembut sering dikenali sebagai organisma yang penting
dalam penyelidikan disebabkan oleh metabolit sekunder yang pelbagai
struktur. Selain itu, ia juga mempunyai pelbagai aktiviti biologi terdiri daripada
potensi antibakteria hingga anti-kanser. Pulau Borneo kaya dengan
kepelbagaian organisma marin termasuk
karang lembut. Oleh itu, satu populasi karang lembut Bornean
genus Nephthea dikumpulkan dari Pulau Mantanani (Sabah, Malaysia)
dan mendapati satu norditerpene baru, chabrolene (1) dan tiga sebatian yang
telah dikenal pasti (2-4). Struktur
kimia untuk keempat-empat sebatian ini dikenal pasti berdasarkan
analisis data spektroskopi NMR dan HREIMS. Sebatian 1 didapati mempunyai
aktiviti penolak terhadap kutu jagung Sitophilus zeamais.
Kata kunci: Aktiviti penolak; karang
lembut; Nephthea sp.; norditerpene; Sitophilus zeamais
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*Pengarang untuk surat-menyurat; email: csv@ums.edu.my
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