Sains Malaysiana 47(6)(2018): 1189–1197

http://dx.doi.org/10.17576/jsm-2018-4706-14

Influence of Poly (Ethylene Glycol) on the Characteristics of γ Radiation-Crosslinked Poly (Vinyl Pyrrolidone)-Low Molecular Weight Chitosan Network Hydrogels

(Kesan Poli(etilena glikol) ke atas Ciri-ciri Jaringan Hidrogel Kitosan Berjisim Molekul
Rendah-Poli(vinil pirolidon)Tertautsilang melalui Teknik Sinar Gamma)

MAZNAH MAHMUD^1,2*, RUSLI DAIK¹ & ZAINAH ADAM²

¹School of Chemical Sciences and Food Technology, Universiti Kebangsaan Malaysia

43600 UKM Bangi, Selangor Darul Ehsan, Malaysia

²Radiation Processing Technology Division, Malaysian Nuclear Agency

43000 Kajang, Selangor Darul Ehsan, Malaysia

³Medical Technology Division, Malaysian Nuclear Agency, 43000 Kajang, Selangor Darul Ehsan

Malaysia

Diserahkan: 9 Jun 2017/Diterima: 8 Januari 2018  

ABSTRACT

PEG at compositions of 10, 15 and 20 g were added into the initial formulation of hydrogel L, which was composed of 6 g low molecular weight chitosan (LMC) and 14 g poly (vinyl pyrrolidone) in 100 g of 2% lactic acid. The mixtures were moulded and exposed to γ radiation at 7 kGy. The hydrogels obtained were characterized in term of gel fraction, swelling property, syneresis effect, FTIR, XRD and cross section morphology. The results indicated PEG reduces almost 27% crosslinking density of the LMC-PVP hydrogel yet increased hydrogel’s water holding capacity from 450% and 480% to 750% and 650% in phosphate buffer solution (PBS) at pH5.5 and pH7.0, respectively. Also PEG enhanced the ability of LMC-PVP hydrogel to retain its moisture from dehydration at body temperature. The morphological study showed PEG developed thick pores wall and reduced the pores size of the hydrogels’ network.

Keywords: Covalent-crosslink; plasticizer; porosity; swelling-equilibrium; syneresis

ABSTRAK

PEG dengan komposisi yang pelbagai iaitu 10, 15 dan 20 g telah ditambah ke dalam formulasi asal hidrogel L yang telah disediakan melalui pengadunan 6 g kitosan berjisin molekul rendah (LMC) dengan 14 g poli (vinil pirolidon) dan 100 g asid laktik berkepekatan 2%. Semua adunan dimasukkan dalam acuan dan didedahkan kepada sinar γ pada dos 7kGy. Hidrogel yang diperoleh dibuat pencirian daripada aspek kandungan gel, sifat pembengkakan, kesan sineresis, FTIR, XRD dan morfologi hidrogel menggunakan mikroskop imbasan elektron (SEM). Keputusan pencirian menunjukkan 10 g PEG telah mengurangkan ketumpatan jaringan taut silangan hidrogel sebanyak 14% tetapi meningkatkan keupayaan memegang air daripada 450% dan 480% kepada 750% dan 650% masing-masing dalam larutan penimbal fosfat (PBS) pada pH5.5 dan pH7.0. PEG juga meningkatkan keupayaan hidrogel LMC-PVP untuk mengekalkan kelembapannya daripada terhidrat pada suhu badan. Kajian morfologi juga menunjukkan PEG telah membentuk satu jaringan hidrogel berliang lebih kecil dengan dinding liang yang lebih tebal.

Kata kunci: Keliangan; pembengkakan ekuilibrium; pemplastik; sineresis; taut silang kovalen

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*Pengarang untuk surat-menyurat; email: maznah@nuclearmalaysia.gov.my