Sains Malaysiana 47(7)(2018): 1563–1569

http://dx.doi.org/10.17576/jsm-2018-4707-26

 

Keratitis Acanthamoeba di Malaysia

(Acanthamoeba Keratitis in Malaysia)

 

MOHAMED KAMEL ABD GHAN1^I*, IRDAWATI AZHAR¹, HALIZA ABDUL MUTALIB¹,

ANISAH NORDIN², YUSOF SUBOH², NORAINA AB RAHIM² & NORAZAH AHMAD³

 

¹Fakulti Sains Kesihatan, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Wilayah Persekutuan, Malaysia

 

²Fakulti Perubatan, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak,

56000 Kuala Lumpur, Wilayah Persekutuan, Malaysia

 

³Institut Penyelidikan Perubatan, Jalan Pahang, 50588 Kuala Lumpur, Wilayah Persekutuan, Malaysia

 

Diserahkan: 21 September 2017/Diterima: 12 Februari 2018

 

 

ABSTRAK

Acanthamoeba spp. merupakan ameba hidup bebas yang tersebar luas di persekitaran. Ameba ini menyebabkan penyakit keratitis terutamanya kepada individu yang memakai kanta sentuh terkontaminasi atau mempunyai sejarah trauma pada mata. Tujuh puluh empat sampel kikisan kornea pesakit keratitis daripada 4 buah hospital di sekitar Lembah Kelang telah dikultur untuk menemukan Acanthamoeba spp. Keputusan kajian mendapati Acanthamoeba spp. berjaya dipencilkan daripada 14.87% sampel kikisan kornea pesakit keratitis. Berdasarkan kajian ini, kesemua pesakit keratitis Acanthamoeba adalah merupakan pemakai kanta sentuh yang majoritinya (90.9%) terdiri daripada kaum wanita. Kanta sentuh lembut terlibat dalam 90.9% kes manakala jenis kanta separa keras cuma satu kes 9.1%. Kesemua 11 pencilan Acanthamoeba yang dipencilkan adalah daripada kumpulan polyphagids yang biasanya patogenik kepada manusia dan menyebabkan jangkitan ini. Kegagalan pengguna kanta sentuh mengamalkan tahap kebersihan kanta sentuh yang baik merupakan faktor risiko yang penting dalam kejadian keratitis Acanthamoeba di Malaysia.

 

Kata kunci: Acanthamoeba; kanta sentuh; keratitis; Malaysia

 

ABSTRACT

Acanthamoeba spp. are ubiquitous free-living amoebae that are commonly found in environment. It may cause keratitis in individual using contaminated contact lens or having history of ocular trauma. Seventy-four samples of corneal scrapings from keratitis patients, from 4 hospitals in Klang Valley were cultured for the isolation of Acanthamoeba. Acanthamoeba spp. were successfully isolated from 14.87% of corneal scraping samples from keratitis patients. This study showed that all of the Acanthamoeba keratitis patients were contact lens wearers majority of whom were women (90.9%). Soft contact lens were implicated in 90.9% of cases while the rigid gas permeable type in only one case (9.1%). All 11 Acanthamoeba isolates were from the polyphagids group which were known to be pathogenic to human. Failure of contact lens users to practice good hygienic care of their lenses attributed to the risk factor for the occurrence of Acanthamoeba keratitis in Malaysia.

 

Keywords: Acanthamoeba; contact lens; keratitis; Malaysia

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*Pengarang untuk surat-menyurat; email: profkamel@ukm.edu.my