Sains Malaysiana 48(3)(2019): 543–553

http://dx.doi.org/10.17576/jsm-2019-4803-06

Fenazin sebagai Potensi Antibiotik Baru daripada Streptomyces kebangsaanensis

(Fenazin as Potential New Antibiotics from Streptomyces kebangsaanensis)

JUWAIRIAH REMALI¹, NORAZIAH MOHAMAD ZIN^2*, CHYAN LEONG NG³, WAN M. AIZAT³ & JOHN J.L TIONG⁴

¹Pusat Pengajian Biosains dan Bioteknologi, Fakulti Sains dan Teknologi, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia

²Pusat Penuaan Sihat dan Kesejahteraan (HCARE), Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Federal Territory, Malaysia

³Institut Biologi Sistem (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia

⁴Pusat Pengajian Farmasi, Universiti Taylor, No. 1, Jalan Taylor's, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia

Diserahkan: 31 Mac 2018/Diterima: 15 November 2018

ABSTRAK

Fenazin merupakan metabolit sekunder yang biasanya disintesis secara semula jadi oleh Pseudomonas dan Streptomyces. Ia merupakan sebatian heterosiklik yang mempunyai sebatian bernitrogen pada struktur teras cecincin. Kajian mengenai antibiotik ini telah bermula seawal abad ke-19 lagi dan ternyata menjadi calon dadah yang berpotensi tinggi dalam dunia perubatan. Sehingga kini, lebih daripada 100 jenis fenazin telah diterokai daripada sumber semula jadi dan boleh bertindak sebagai antibakteria, antikanser, antivirus, antitumor serta antiparasit. Setakat ini, kajian biosintesis fenazin yang telah dijalankan terhadap Pseudomonas dan Streptomyces telah mendedahkan gen yang bertanggungjawab dalam tapak jalan biosintesis fenazin, namun begitu, gen khusus yang terlibat dalam penghasilan terbitan fenazin yang kompleks masih dalam hipotesis. Dalam ulasan ini, kami membincangkan kepentingan fenazin serta pemahaman terkini tentang tapak jalan biosintesis fenazin yang berjaya diterokai di dalam Streptomyces kebangsaanensis.

Kata kunci: Antibiotik; biosintesis; fenazin; Streptomyces kebangsaanensis

ABSTRACT

Phenazine is a secondary metabolite that is naturally synthesized by Pseudomonas and Streptomyces. It is a heterocyclic compound that has nitrogen group at the core structure of the ring. The study of antibiotics has begun since 19th century and turned out to be a highly potential drug in a medical world. To date, more than 100 types of phenazines have been discovered from natural sources and acted as antibacterial, anticancer, antiviral, antitumor and antiparasites. To date, the study of phenazine biosynthesis was carried out on Pseudomonas and Streptomyces has showed the genes responsible in the pathway of phenazine biosynthesis but the specific genes involved in the production of complex phenazine derivatives are still hypothetical. In this review, we discuss the importance of phenazine as well as the latest understanding of phenazine biosynthesis pathways that have been successful discovered in Streptomyces kebangsaanensis.

Keywords: Antibiotics; biosynthesis; phenazine; Streptomyces kebangsaanensis

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