Sains Malaysiana 48(8)(2019): 1753–1759

http://dx.doi.org/10.17576/jsm-2019-4808-22

Synthesis and Characterizations of Hydrophilic pHEMA Nanoparticles via Inverse Miniemulsion Polymerization

(Sintesis dan Pencirian Zarah Nano Hidrofil pHEMA melalui Pempolimeran Miniemulsi Songsang)

ZALIKHA ISMAIL¹ & NOOR ANIZA HARUN^1,2*

¹Faculty of Science & Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu Darul Iman, Malaysia

²Advance NanoMaterials (ANOMA) Research Group, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu Darul Iman, Malaysia

Diserahkan: 7 Februari 2019/Diterima: 26 Mei 2019

ABSTRACT

This study highlights on the development of hydrophilic polymer nanoparticles prepared via inverse miniemulsion polymerization, a robust technique to prepare hydrophilic and aqueous-soluble polymeric nanoparticles. 2-hydroxyethyl methacrylate (HEMA) is excellent candidate for homo-polymerization due to its biocompatibility and biodegradability characteristic with high hydrophilicity properties. The influence of synthesis parameters including the effects of sonication time ranging from 10 - 30 min and sonication amplitude up to 60% towards the particles size and morphology of pHEMA nanoparticles are investigated. The formation of pHEMA nanoparticles are confirmed by Fourier Transform Infrared (FTIR). The morphology of polymer nanoparticles has been determined using Scanning Electron Microscope (SEM) and Transmission Electron Microscopy (TEM). Dynamic light scattering (DLS) indicates the mean diameters of pHEMA nanoparticles were in a range of 100 - 200 nm. The hydrophilic polymer nanoparticles obtained are expected to facilitate in the fabrication of inorganic-polymer composite nanoparticles especially in biological applications.

Keywords: HEMA; hydrophilic; inverse miniemulsion; nanoparticles

ABSTRAK

Kajian ini menonjolkan pembangunan zarah nano polimer dengan ciri hidrofil yang lebih baik yang disediakan melalui pempolimeran miniemulsi songsang, suatu teknik yang teguh untuk menyediakan zarah nano polimer hidrofil dan larut akueus. 2-hidroksi metakrilat (HEMA) adalah bahan yang sangat baik untuk pempolimeran-homo kerana sifat biokeserasian dan biodegradasi dengan sifat hidrofil yang tinggi. Pengaruh parameter sintesis termasuk kesan masa sonikasi antara 10 - 30 min dan amplifikasi sonikasi sehingga 60% ke arah saiz zarah dan morfologi zarah nano pHEMA dikaji. Pembentukan zarah nano pHEMA disahkan oleh Spektroskopi Inframerah Transformasi Fourier (FTIR). Morfologi zarah nano polimer telah ditentukan menggunakan Mikroskop Elektron Imbasan (SEM) dan Mikroskop Elektron Transmisi (TEM). Penyebaran cahaya dinamik (DLS) menunjukkan diameter purata zarah nano pHEMA berada dalam lingkungan 100 - 200 nm. Zarah nano polimer hidrofilik yang diperoleh dijangka memudahkan dalam fabrikasi zarah nano komposit polimer-bukan organik terutamanya dalam aplikasi biologi.

Kata kunci: HEMA; hidrofilik; pempolimeran songsang; zarah nano

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*Pengarang untuk surat-menyurat; email: nooraniza@umt.edu.my