Sains Malaysiana 49(2)(2020): 411-420

http://dx.doi.org/10.17576/jsm-2020-4902-20

In vitro Study of Anti-Helicobacter pylori Activity of Honey: A Systematic Review

(Kajian In vitro Aktiviti Anti-Helicobacter pylori Madu: Ulasan Sistematik)

ADAM QURAISIAH¹, ANNUAR FAZALDA¹, HANAFIAH ALFIZAH² & MOHD FAHAMI NUR AZLINA¹*

¹Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Federal Territory, Malaysia

²Department of Medical Microbiology & Immunology, Faculty of Medicine, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Federal Territory, Malaysia

Diserahkan: 6 Mei 2019/Diterima: 4 November 2019

ABSTRACT

This review explores the beneficial effects of honey on Helicobacter pylori-induced gastric ulcer and duodenal ulcer. The research of the effectiveness of honey on H. pylori infection using electronic databases was done, these include Medline via Ovid Medline, Scopus and ScienceDirect published from the year 2000 to 2018. The articles were evaluated and selected based on the criteria which report on the effects of honey on gastric ulcer and duodenum ulcer caused by H. pylori infection. There are 53 articles were identified, which stated to the studies that relate to the criteria. Afterwards, nine articles on honey and its extracts were selected and assessed accordingly in this review. All studies reported positive effects of honey on H. pylori-induced gastric ulser and duodenal ulcer. Most of the studies showed at minimum 10% of honey concentration were effective as anti-H. pylori activity. This systematic review emphasized the potential of honey used to inhibit the H. pylori infection in-vitro. Future extensive studies are required to find the active component and molecular mechanism of honey before animal and human observational studies could be conducted to deliver valid evidence.

Keywords: Duodenal ulcer; gastric cancer; gastric ulcer; gastritis; Helicobacter pylori; honey

ABSTRAK

Ulasan ini adalah untuk mengkaji kesan manfaat madu pada Helicobacter pylori teraruh ulser gaster dan ulser duodenal. Satu kajian terhadap keberkesanan madu pada jangkitan H. pylori menggunakan pangkalan data elektronik telah dilakukan, ini termasuklah Medline melalui Ovid Medline, Scopus dan ScienceDirect yang telah diterbitkan dari tahun 2000-2018. Artikel telah dinilai dan dipilih berdasarkan kriteria yang melaporkan mekanisme dan kesan madu pada ulser gaster dan ulser duodenal yang disebabkan oleh jangkitan H. pylori. Terdapat 53 artikel telah dikenal pasti yang merujuk kepada kajian yang sepadan dengan kriteria. Seterusnya, sembilan artikel mengenai madu dan ekstrak madu telah dipilih dan dinilai sewajarnya dalam kajian ini. Semua kajian melaporkan kesan positif pada madu terhadap H. pylori yang berpunca daripada ulser gastrik dan ulser duodenal. Kebanyakan kajian menunjukkan sekurang-kurangnya kepekatan madu sebanyak 10% berkesan sebagai aktiviti anti-H. pylori. Kajian sistematik ini menekankan potensi madu yang digunakan untuk merencatkan jangkitan H. pylori secara in-vitro. Kajian menyeluruh pada masa akan datang adalah perlu untuk mencari komponen aktif dan mekanisme molekul yang ada pada madu sebelum kajian pengamatan terhadap haiwan dan manusia dijalankan untuk memberi bukti yang sah.

Kata kunci: Gastritis; Helicobacter pylori; kanser gaster; madu; ulser duodenal; ulser gaster

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*Pengarang untuk surat-menyurat; email: nurazlinamf@ukm.edu.my