The Malaysian Journal of Analytical Sciences Vol 13 No 1 (2009): 73 - 85

 

 

 

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND TOXICITY STUDIES OF NOVEL ORGANOTIN(IV) COMPLEXES DERIVED FROM BENZOYLACETONE ISONICOTINYLHYDRAZONE (H₂BAS): X-RAY CRYSTAL STRUCTURE OF [Me₂Sn(BAS)]

 

M.A. Affan¹*, I.P.P. Foo¹, B.A. Fasihuddin¹, E.U.H. Sim¹, M.A. Hapipah²

 

¹Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia.

²Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

 

*Corresponding author: maaffan@frst.unimas.my

 

Abstract

Six organotin(IV) complexes, [R_mSnCl_2-m(BAS)], where R_m = Me₂ (2), nBu₂ (3), Ph₂ (4), Me (5), nBu (6) and Ph (7) have been synthesized by direct reaction of organotin(IV) halide(s) with benzoylacetone isonicotinylhydrazone ligand [(H₂BAS), (1)] with the presence of KOH in 1:2:1 (ligand:base:metal) mole ratio in absolute methanol. The hydrazone ligand [(H₂BAS), (1)] and its organotin(IV) complexes (2-7) have been characterized by elemental analyses, UV-Visible, IR and ¹H NMR spectral studies. All organotin(IV) complexes (2-7) are non electrolytic in nature. Among them, molecular structure of dimethyltin(IV) complex, [Me₂Sn(BAS)] (2) has also been studied by X-ray single crystal diffraction. Preliminary toxicity test showed that the organotin(IV) complexes (2-7) are more toxic against the Artemia salina than the free hydrazone ligand [(H₂BAS), (1)].

 

Keywords: Hydrazone ligand; organotin(IV) complexes; spectral studies; crystal structure; toxicity test

 

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