Sains Malaysiana 47(6)(2018): 1109–1115

http://dx.doi.org/10.17576/jsm-2018-4706-05

Potensi Afrodisiak Lunasia amara ke atas Tikus Jantan Teraruh Diabetes

(Aphrodisiac Potential of Lunasia amara on Diabetic-Induced Male Rats)

NOR-RAIDAH RAHMAT, AMIRA KAMALRUDIN, SHAZRUL FAZRY & MAHANEM MAT NOOR*

Pusat Pengajian Biosains dan Bioteknologi, Fakulti Sains dan Teknologi

Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia

Received: 21 September 2017/Accepted : 8 February 2018

ABSTRAK

Diabetes melitus telah terbukti mengganggu penghasilan testosteron dan menyebabkan masalah libido dalam kalangan lelaki. Sehingga kini, tiada kajian mengenai potensi Lunasia amara dalam membaiki aktiviti seksual tikus jantan teraruh diabetes. Oleh itu, kajian ini dijalankan untuk mengenal pasti potensi afrodisiak L. amara ke atas tikus jantan teraruh diabetes. Empat kumpulan tikus teraruh diabetes masing-masing diberi perlakuan ekstrak L. amara (250 dan 500 mg/kg berat tubuh), 500 mg/kg metformin dan air suling. Tikus kumpulan kawalan normal tanpa aruhan diabetes menerima perlakuan air suling. Perlakuan diberikan secara suap paksa selama 30 hari untuk melihat kesan L. amara ke atas status libido, aras testosteron serum, berat tubuh tikus, morfometri testis dan epididimis kauda serta aktiviti enzim antioksida testis tikus teraruh diabetes berbanding kawalan. Keputusan kajian menunjukkan berlaku penurunan libido, aras testosteron, dan aktiviti khusus enzim antioksida (glutation peroksidase, katalase dan superoksida dismutase) testis tikus teraruh diabetes secara signifikan (p<0.05) pada kedua-dua dos tersebut berbanding kawalan normal. Sementara itu, perlakuan L. amara didapati tidak menjejaskan morfometri testis, epididimis kauda dan berat tubuh tikus yang menerima perlakuan L. amara berbanding kawalan normal. Kajian ini membuktikan bahawa ekstrak akuas batang L. amara pada dos 250 dan 500 mg/kg berat tubuh tidak berupaya memperbaiki aktiviti seksual tikus jantan teraruh diabetes.

Kata kunci: Afrodisiak; diabetes melitus; libido; Lunasia amara

ABSTRACT

Accumulating evidence shows that diabetes mellitus alters the production of testosterone and contributes to the reduction of libido in male. Formerly, no study has been conducted on the effect of Lunasia amara on sexual activity in diabetic-induced male rats. Therefore, present study looked into the aphrodisiac potential of L. amara on diabetic-induced male rats. Four groups of diabetic-induced male rats were given L. amara aqueous extract (250 and 500 mg/kg body weight), 500 mg/kg metformin and distilled water, respectively. A group of control rats was given distilled water. Treatments were given for 30 days to investigate the effect of L. amara aqueous extract on libido, serum testosterone level, body weight, morphometry of testis, cauda epididymis and antioxidant enzymes activity in diabetic-induced rats in comparison to control. The result showed diabetic-induced rats treated with both doses of L. amara extract exhibit significant reduction (p<0.05) in libido, testosterone level, testis antioxidant enzymes activity (glutathione peroxidase, catalase and superoxide dismutase) compared to control. On the other hand, the administration of L. amara did not affect body weight, morphometry of testis and cauda epididymis of diabetic-induced rats compared to normal control. This findings suggested that L. amara at doses 250 and 500 mg/kg body weight is incapable of improving sexual activity in diabetic-induced male rats.

Keywords: Aphrodisiac; diabetes mellitus; libido; Lunasia amara

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*Corresponding author; email: mahanem@ukm. edu.my