Sains Malaysiana 48(7)(2019): 1439–1446

http://dx.doi.org/10.17576/jsm-2019-4807-13

Synthesis, Characterization and Biological Activities of Hydrazone Schiff Base and its Novel Metals Complexes

(Sintesis, Pencirian dan Aktiviti Biologi Hidrazon Pangkal Schiff serta Kompleks Baru Logamnya)

IQBAL HUSSAIN¹, AAQIB ULLAH¹, ATTA ULLAH KHAN¹, WALI ULLAH KHAN², RIAZ ULLAH^3*, ABDELAATY A. SHAHAT ALMOQBIL A. NASER^3,4 & HAFIZ MAJID MAHMOOD⁵

¹Department of Chemistry, Islamia College University Peshawar, Pakistan

²Department of Chemistry, Abdul Wali Khan University Mardan, Pakistan

³Department of Pharmocognosy (Medicinal, Aromatic and Poisonous Plants Research Center), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

⁴Phytochemistry Department, National Research Centre, P.O. Box 1262233, El Bohouth St., Dokki, Giza, Egypt

⁵Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

Received: 15 January 2019/Accepted: 24 April 2019

ABSTRACT

Recently, researchers are focusing on the synthesis of Schiff base complexes due to their promising biological activities and frequent use in the pharmaceuticals. In the present study we synthesized Schiff base of salicyldehyde and 2, 4-dinitrophenylhydrazine by modified method and its novel metal complexes with Cu (II), Zn (II), Co (II), Ni (II), Mn (II), V (II) and AU (IIII). For spectroscopic studies and characterization, UV-Vis and FT-IR spectroscopy were used. The Schiff base and its metals complexes were tested for antimicrobial, cytotoxic and antioxidant activities. Significant results are showed by the all synthesized complexes.

Keywords: Biological activities; IR spectroscopy; Schiff base; UV-visible

ABSTRAK

Baru-baru ini penyelidik menumpukan perhatian kepada sintesis kompleks pangkal Schiff disebabkan oleh aktiviti biologi yang berpotensi dan kerap digunakan dalam bidang farmaseutis. Dalam kajian ini, Schiff pangkal salisildehid dan 2, 4-dinitrofenilhidrazin disintesis menggunakan kaedah ubah suai dan kompleks baru logamnya dengan Cu (II), Zn (II), Co (II), Ni (II), Mn (II), V (II) dan AU (IIII). Untuk kajian spektroskopi dan pencirian, UV-Vis dan Spektroskopi FT-IR telah digunakan. Pangkal Schiff dan kompleks logam telah diuji untuk aktiviti antimikrob, sitotoksik dan antioksidan. Hasil ketara telah ditunjukkan oleh semua kompleks yang telah disintesis.

Kata kunci: Aktiviti biologi; pangkal Schiff; spektroskopi IR; UV Nampak

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*Corresponding author; email: rullah@ksu.edu.sa