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Sains
Malaysiana 49(2)(2020): http://dx.doi.org/10.17576/jsm-2020-4902-18
Clinical Significance of Blood Supply of the Fornix of Brain: A
Cadaveric Study
(Keertian
Klinikal Pembekuan Darah Forniks Otak: Suatu Kajian Kadaverik)
PATCHARAPORN SRISAIKAEW1,2, TANAT
VANIYAPONG3, SRIJIT DAS4 & PASUK MAHHAKRANUKRAUH1,5,6*
1PhD
Degree Program in Anatomy, Faculty of Medicine, Chiang Mai University, Chiang
Mai, 52000, Thailand
2Department
of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 52000, Thailand
3Division
of Neurosurgery, Department of Surgery, Faculty of Medicine, Chiang Mai
University, Chiang Mai, 52000, Thailand
4Department
of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif,
Bandar Tun Razak, 56000 Kuala Lumpur, Federal Territory, Malaysia
5Forensic
Osteology Research Center, Faculty of Medicine, Chiang Mai University, Chiang
Mai, 50200, Thailand
6Research
Cluster in Osteology Research and Training Center (ORTC), Chiang Mai University,
Chiang Mai, 50200, Thailand
Received: 21 September 2019/Accepted: 5 November 2019
Abstract
Transient
ischemic attack (TIA) of the fornix causes a spectrum of memory deficits, which
increases the contributions of vascular disease to dementia which is known as
early-onset dementia. As the fornix, the
white matter bundle, serves as the major efferent pathway connecting the
hippocampus with other human limbic structures, a variety of lesions that
damage the fornix could lead to significant memory impairment. Therefore, the blood
supply of fornix is a concern. This study aims to study the arterial supply of
fornix. Thirty fresh human cadaveric heads were used. They were preserved by the mixture of
fixation solution for fornix anatomical dissection and injected with coloured latex
solution for visualization of cerebral vasculature through 6 critical steps of
approaches. The result showed that the
fimbriae of fornix were mainly supplied by the branches of posterior cerebral
artery (PCA) and two cases were found to have the anastomoses of those branches
with the choroidal artery (ChA). The proposed technique confirmed the ability
of coloration of human cerebral vasculature by using colored latex solution
which penetrated into cerebral small vessels leading to a precise understanding
of the arterial supply of fornix in human brain which is essential for
neurosurgeon, neurosurgical training and researchers.
Keywords: Arteries; brain; fixation; fornix;
latex injection
Abstrak
Serangan
iskemik sementara (TIA) di fornix menyebabkan pelbagai spektrum defisit memori
yang secara langsung meningkatkan sumbangan penyakit vaskular kepada demensia
yang juga dikenali sebagai demensia permulaan-awal. Oleh kerana fornix terdiri
daripada kumpulan jirim putih yang berfungsi sebagai laluan eferen utama yang
menghubungkan hipokampus dengan struktur limbik manusia yang lain, kecederaan
yang merosakkan fornix boleh mengakibatkan kerosotan memori yang ketara. Oleh
itu, bekalan darah fornix menjadi kebimbangan. Tujuan penyelidikan ini adalah
untuk mengkaji bekalan saluran darah arteri fornix. Tiga puluh kepala daripada
kadaver yang segar telah digunakan. Setiap kepala diawetkan dengan campuran
cecair fiksasi untuk pembedahan anatomi fornix dan disuntik dengan larutan
lateks berwarna untuk memvisualisasikan vaskular serebrum melalui pendekatan 6
langkah yang kritikal. Hasil kajian ini menunjukkan bahawa fimbria fornix
kebanyakannya dibekalkan oleh rangkaian arteri serebral posterior (PCA) dan
terdapat dua kes dengan penyambungan cabang arteri ini bersama dengan arteri
koroid (ChA) dijumpai. Teknik yang dikemukakan ini mengesahkan keupayaan
pewarnaan vaskular serebrum manusia dengan menggunakan larutan lateks berwarna
yang boleh menembusi salur darah kecil serebral dan membawa kepada pemahaman
yang terperinci terhadap bekalan saluran darah arteri fornix di dalam otak
manusia yang terbukti penting untuk pakar bedah saraf, latihan bedah saraf dan
untuk para penyelidik.
Kata
kunci: Arteri; fiksasi; fornix; otak; suntikan lateks
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*Corresponding author; email: pasuk034@gmail.com |
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