Sains Malaysiana
47(2)(2018): 323-336
http://dx.doi.org/10.17576/jsm-2018-4702-15
Recent Advances in the
Use of Animal-Sourced Gelatine as Natural Polymers for Food, Cosmetics and
Pharmaceutical Applications
(Kemajuan Terkini dalam Penggunaan
Sumber Gelatin Haiwan sebagai Polimer Semula Jadi untuk Aplikasi Makanan,
Kosmetik dan Farmaseutik)
MOHD SHAKRIE
PALAN ABDULLAH1,2, MOHAMED IBRAHIM NOORDIN1, SYED IBRAHIM
MOHD ISMAIL3, NUR MURNISA MUSTAPHA4, MALINA JASAMAI5,
MOHD FAIRUZ DANIK6, WAN AZMAN WAN ISMAIL6 & AHMAD
FUAD SHAMSUDDIN6,7*
1Department of Pharmacy, Faculty of
Medicine, University of Malaya, 50603 Kuala Lumpur, Federal Territory, Malaysia
2Pharmacy Enforcement Branch, Pharmacy
Services Division, Kelantan State Health Department, 16100 Kota Bharu, Kelantan
Darul Naim, Malaysia
3Ain Medicare Sdn. Bhd., Kawasan
Perindustrian Pengkalan Chepa 2, 16100 Kota Bharu, Kelantan Darul Naim,
Malaysia
4Department of Pharmacy, Raja Perempuan
Zainab II Hospital, 15100 Kota Bharu, Kelantan Darul Naim, Malaysia
5Drug and Herbal Research Centre, Faculty
of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala
Lumpur, Federal Territory, Malaysia
6Centre for Drug Delivery Research, Faculty
of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Federal Territory, Malaysia
7Faculty of Pharmacy and Health Sciences,
Universiti Kuala Lumpur, Royal College of Medicine Perak, (UniKL
RCMP), Jalan Greentown, 30450 Ipoh, Perak Darul Ridzuan, Malaysia
Diserahkan: 11 Mei 2017/Diterima: 21 Ogos
2017
ABSTRACT
Gelatine
is used as an excipient for various pharmaceutical dosage forms, such as
capsule shells (both hard and soft), tablets, suspensions, emulsions and
injections (e.g. plasma expanders). It is also broadly used in various
industries such as food and cosmetics. Gelatine is a biopolymer obtained from
discarded or unused materials of bovine, porcine, ovine, poultry and marine
industrial farms. The discarded materials can be the skin, tendons, cartilages,
bones and connective tissues. Gelatine sourced from animals is relatively easy
and inexpensive to produce. The potential needs of gelatine cannot be
overemphasised. Rising demands, health concerns and religious issues have
heightened the need for alternative sources of gelatine. This review presents
the various industrial uses of gelatine and the latest developments in
producing gelatine from various sources.
Keywords: Cosmetics;
food; gelatine, injections;
pharmaceuticals; plasma expanders
ABSTRAK
Gelatin diguna
sebagai eksipien (bahan tambahan) dalam pelbagai bentuk dos farmaseutik seperti
kelongsong kapsul (keras dan lembut), tablet, ampaian (suspensi), emulsi dan
suntikan (contoh: pengembang plasma). Ia juga diguna dalam pelbagai industri
lain seperti industri makanan dan kosmetik. Gelatin adalah biopolimer yang
diperoleh daripada bahan-bahan terbuang atau yang tidak diguna daripada haiwan
ternakan termasuk lembu, porsin, ovin, unggas dan ikan. Bahan-bahan terbuang
ini adalah seperti kulit, tendon, rawan, tulang dan tisu penghubung. Gelatin
daripada sumber haiwan adalah agak mudah dan murah untuk dihasilkan. Potensi
gelatin tidak dapat dinafikan. Permintaan yang semakin meningkat, masalah
kesihatan dan isu-isu agama telah meningkatkan keperluan untuk sumber
alternatif gelatin. Tinjauan ini membentangkan pelbagai kegunaan gelatin dalam
industri dan perkembangan terkini dalam penghasilan gelatin daripada pelbagai
sumber.
Kata kunci: Farmaseutik; gelatin; kosmetik; makanan; penambah plasma; sumber
alternatif
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*Pengarang untuk surat-menyurat;
email: fuad.shamsuddin@unikl.edu.my
