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Sains Malaysiana 47(4)(2018): 749-754 http://dx.doi.org/10.17576/jsm-2018-4704-13 Synthesis of Cephradine Metal Complexes
and its Anti-bacterial Evaluation (Sintesis Kompleks Logam Sefradin dan Penilaian
Anti-bakteria) IQBAL HUSSAIN1, SYED
SALMAN1, SARWAT IFTIKHAR2, SAMIN JAN2,
JUNAID AKHTER3, MUHAMMAD RAMZAN1, ATTA ULLAH4,
RIAZ ULLAH5,6*, MANSOUR S. ALSAID5,6 ABDELAATY
A. SHAHAT5,7 & SYED HIDAYATHULLA5,6 1Department of Chemistry, Islamia College Peshawar Jamrud Road, Peshawar, 25120 Pakistan 2Department of Botany Islamia College Peshawar, Jamrud Road, Peshawar, 25120 Pakistan 3Department of Chemistry, Kohat University of Science & Technology, Kohat Pakistan, 26000 Khyber Pakhtunkhwa Pakistan 4Department of
Chemistry Islamia College, Peshawar Jamrud Road,, Peshawar, 25120
Pakistan 5Department of Pharmacognosy and Medicinal, Aromatic & Poisonous Plants Research Center MAPPRC) College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451 Saudi Arabia 6Department of Chemistry Government College Ara Khel FR Kohat, KPK, Pakistan 7Phytochemistry Department, National Research Centre 33 El Bohouth st. P.O. Box 12622 Dokki, Giza Egypt Diserahkan: 19 April 2017/Diterima: 11 November 2017 ABSTRACT Cephradine belongs
to the first generation cephalosporin having a broad range of anti-bacterial
activities. In the present work,
Cephradine wasreacted with
different metal
salts. These
metal salts
were Iron,
Copper,
Cobalt and Nickel salts. All the complexes of Cephradine
metals were synthesized at room temperature using a mechanical vibrator.
The reactions yielded the coordinated complexes within 5-10
min with improved product yield. The synthesized complexes
were analyzed
for their antibacterial power using disc
diffused assay.
All the
Cephradine complexes
showed powerful antibacterial activity. The Co, Cu, Ni and
Sn complexes showed good antibacterial activities 18.5 mm by Cu
complexes against S. typhi, 17 mm against
B. subtillus 16.5 mm against
S. aureus, 16 mm against
S. coccus. Similarly Sn complexes exhibited 17 mm zone
of inhibition against S. coccus
and 15.5 mm against B. subtillus.
Cobalt and Ni complexes also shed significant inhibition activities
against bacterial pathogenic bacterial strains. The study is of
particular importance and new,
using mechanical vibrator for the first time. The product
yield is also comparatively good with short reaction
time. Keywords: Cephalosporin; cephradine; complexation; penicillinase;
synthesis ABSTRAK Sefradin tergolong dalam
sefalosporin generasi pertama
yang mempunyai pelbagai
aktiviti antibakteria. Dalam
kertas ini, Sefradin telah menggunakan garam logam yang berlainan.
Garam logam ini adalah besi, tembaga, kobalt dan garam nikel. Semua
kompleks logam Sefradin telah
disintesis pada suhu bilik dengan menggunakan alat vibrator mekanikal.
Reaksi menghasilkan kompleks yang diselaraskan dalam masa 5-10 minit
dengan hasil produk yang lebih baik.
Kompleks yang
disintesis telah
dianalisis untuk
kuasa antibakteria mereka menggunakan ujian
disebarkan cakera. Semua kompleks Sefradin menunjukkan aktiviti antibakteria yang
kuat. Kompleks Co, Cu, Ni dan Sn menunjukkan aktiviti antibakteria
yang baik 18.5 mm oleh kompleks Cu terhadap S.
typhi, 17 mm terhadap B.
subtilus 16.5 mm terhadap S. aureus, 16 mm terhadap S.
coccus. Begitu juga kompleks Sn mempamerkan zon perencatan 17 mm terhadap S. coccus dan 15.5 mm terhadap B. subtilus. Kobalt dan Ni kompleks juga menimbulkan aktiviti penghambatan yang ketara
terhadap strain
bakteria patogenik bakteria. Kajian ini amat
penting dan baru serta
menggunakan alat vibrator mekanikal untuk kali pertama. Hasil
produk juga agak baik dengan masa reaksi yang pendek. Kata kunci: Kompleks; penisilinase; sefalosporin;
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