Sains Malaysiana 38(1): 57-59(2009)

Evaluation of Diuretic Potential of Nephrolepis cordifolia

rhizome Juice in Wistar Rats

(Penilaian Potensi Diuretik Jus Rizom Nefrolepis kordifolia Jus

Rizom Terhadap Tikus Wistar)

A.    Rajasekaran

School of Pharmacy, AIMST University

Bukit Air Nasi, Jalan Bedong Semeling

08100, Bedong, Kedah Darul Aman, Malaysia

Received:  17 March 2008 / Accepted:  27 May 2008

ABSTRACT

Nephrolepis cordifolia rhizome (sword fern) juice was investigated for diuretic activity in wistar rats. Different parameters viz. total urine volume (corrected for water intake during the test period), urine concentration of electrolytes such as sodium, potassium and chloride have been evaluated. Rhizome juice of Nephrolepis cordifolia (100 mg/kg), the reference drug, furosemide (20 mg/kg) was administrated orally to male Wistar rats and their urine output was quantitated at several intervals of time after the dose. After single dose of the rhizome juice of Nephrolepis cordifolia, urine output was significantly increased. Increase in urinary levels of Na⁺, K⁺ and Cl^- was also observed after the administration of rhizome juice.

Keywords: Diuretic activity; Nephrolepis cordifolia; rhizome juice extract

ABSTRAK

Kesan jus rezom Nefrolepis cordifolia rizom terhadap aktiviti diuretic dalam tikus wistar telah dikaji. Parameter berlainan iaitu jumlah isipadu kencing (dibetulkan terhadap pengambilan air semasa ujian) dan kepekatan elektrolit seperti natrium, kalium dan klorida telah diukur. Jus rizom Nefrolepis kordifolia (100 mg/kg), dadah rujukan, furosemid (20 mg/kg) telah diberikan secara oral kepada tikus Wistar jantan dan output kencing telah dikira pada beberapa sela masa selepas setiap dos. Selepas setiap dos jus rizom Nefrolepis kordifolia output kencing meningkat dengan ketara. Peningkatan dalam aras Na⁺, K⁺ dan Cl^- telah dicerap selepas jus rizom diberikan.

Kata kunci:  Aktiviti diuretik; ekstrak jus rizom; Nefrolepis kordifolia

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