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Sains Malaysiana 49(4)(2020): 825-838
http://dx.doi.org/10.17576/jsm-2020-4904-12
Mesenchymal Stem
Cell Therapy for Sports Injuries - From Research to Clinical Practice
(Terapi Sel Stem Mesenkima untuk Kecederaan Sukan - Daripada Kajian kepada Amalan Klinikal)
QI HAO LOOI1, SUE PING ENG1,
LING LING LIAU2, YIN SIM TOR3,
MOHD YAZID BAJURI4, MIN HWEI NG5 & JIA XIAN LAW5*
1Ming
Medical Services Sdn. Bhd., Pusat Perdagangan Dana 1, 47301 Petaling Jaya Selangor Darul Ehsan, Malaysia
2Physiology
Department, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur, Federal Territory, Malaysia
3School of Biosciences, Faculty of Health & Medical Sciences,
Taylor’s University, 47500 Subang Jaya,
Selangor Darul Ehsan, Malaysia
4Orthopaedic
Department, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur, Federal Territory, Malaysia
5Tissue
Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur Federal Territory, Malaysia
Diserahkan:
15 Mei 2019/Diterima: 19 Disember 2019
Abstract
The number of sports-related
injuries is on the rise as more people are involved in sports, especially the
extreme sports that are prone to injury. A serious sports injury might end the
career of an athlete. Thus, prompt and effective treatment is very important
for these injuries. Cell-based therapy is becoming more popular as a potential
new treatment for sports injuries that are refractory to conventional therapy.
Mesenchymal stem cells (MSCs) are commonly used in the treatment of sports injuries as they are safe and will not be rejected by the
recipient. MSCs secrete paracrine factors that modulate the host immune
response, promote angiogenesis, enhance cell migration and survival as well as
prevent fibrosis. The safety and efficacy of MSC therapy in treating sports
injuries involving the muscle, ligament, tendon, bone, cartilage, and nervous tissues have been demonstrated in many preclinical and clinical
studies. However, more studies especially the large-scale randomized clinical
trial need to be done in order to determine the
adequacy of MSC therapy in treating different sports injuries. In this review,
we discussed the treatment for sports injuries, focusing on MSC therapy, using
data from preclinical and clinical studies.
Keywords: Mesenchymal stem cell; orthopedics;
regenerative medicine; sports injury; stem cell therapy
Abstrak
Bilangan kes kecederaan berkaitan
dengan sukan semakin meningkat sejajar dengan peningkatan bilangan orang yang
aktif dalam sukan, terutamanya sukan lasak yang senang tercedera. Kerjaya
seorang atlet mungkin ditamatkan oleh kecederaan berkaitan dengan sukan yang
serius. Oleh yang demikian, rawatan segera dan berkesan amat penting
untuk kecederaan ini. Terapi sel menjadi semakin popular sebagai rawatan
baharu untuk kecederaan berkaitan dengan sukan yang
refraktori kepada terapi konvensional. Sel induk mesenkima (MSC) kerap
digunakan untuk rawatan kecederaan berkaitan dengan sukan kerana ia adalah
lebih selamat dan tidak akan ditolak oleh sistem imun penerima. MSC merembeskan
faktor parakrin yang memodulasi tindak balas imuniti,
merangsang angiogenesis, migrasi sel dan kemandirian sel serta mencegah
fibrosis. Keselamatan dan efikasi terapi MSC dalam merawat kecederaan berkaitan
dengan sukan yang melibatkan tisu otot, ligamen, tendon, tulang, rawan dan
saraf telah ditunjukkan dalam banyak kajian praklinikal dan klinikal. Namun
demikian, lebih banyak kajian terutamanya percubaan klinikal terawak berskala
besar perlu dijalankan untuk mengenal pasti kepadanan terapi MSC
dalam menangani kecederaan berkaitan dengan sukan yang berbeza. Di sini kami membincangkan
rawatan untuk kecederaan berkaitan dengan sukan menggunakan data daripada kajian
preklinikal dan klinikal dengan fokus diberikan kepada terapi MSC.
Kata
kunci: Kecederaan
berkaitan dengan sukan; sel induk mesenkima; ortopedik; perubatan regeneratif;
terapi sel
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*Pengarang untuk surat-menyurat: email; danieljx08@gmail.com
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